Evidence map›Paper›PMID 40592473›Full record

ArticleNature2025

Architecture, dynamics and biogenesis of GluA3 AMPA glutamate receptors.

Aditya Pokharna, Imogen Stockwell, Josip Ivica, Bishal Singh, Johannes Schwab, Carlos Vega-Gutiérrez, Beatriz Herguedas, Ondrej Cais, James M Krieger, Ingo H Greger

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Efficient and rapid isolation of native AMPA receptor complexes for cryo-EM.Protein science : a publication of the Protein Society · 2026
    Article
  8. Review
  9. Frontiers in cellular neuroscience · 2026
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aditya Pokharna *Neurobiology Division, Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0001-9895-3966
Imogen Stockwell *Neurobiology Division, Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, UK.
Josip IvicaNeurobiology Division, Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, UK.
Bishal SinghNeurobiology Division, Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0001-5760-6765
Johannes SchwabStructural Studies Division, Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, UK.
Carlos Vega-GutiérrezInstitute for Biocomputation and Physics of Complex Systems and Laboratory of Advanced Microscopies, University of Zaragoza, Zaragoza, Spain.
Beatriz HerguedasInstitute for Biocomputation and Physics of Complex Systems and Laboratory of Advanced Microscopies, University of Zaragoza, Zaragoza, Spain.ORCID 0000-0003-2044-4795
Ondrej CaisNeurobiology Division, Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, UK.
James M KriegerBiocomputing Unit, National Center of Biotechnology, CSIC, Madrid, Spain.ORCID 0000-0001-6194-6244
Ingo H GregerNeurobiology Division, Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, UK. ig@mrc-lmb.cam.ac.uk.ORCID 0000-0002-7291-2581

Funding

Medical Research CouncilWellcome Trust 223194
6 · The paper itself

Abstract

AMPA-type glutamate receptors (AMPARs) mediate the majority of excitatory neurotransmission in the brain

Indexed as

Cryoelectron MicroscopyReceptors, AMPAAnimalsCalciumHEK293 CellsHumansLigandsMiceModels, MolecularProtein DomainsProtein MultimerizationCalciumglutamate receptor ionotropic, AMPA 3LigandsReceptors, AMPA

Identifiers

PMID40592473
PMCPMC12422969

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.