ArticleObstetrics & gynecology science2025
Identification of volatile organic compound as a novel modality for cervical cancer detection.
Article in Obstetrics & gynecology science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
objectiveIn this study, we developed a novel detection strategy based on volatile organic compound (VOC) sensing. Persistent infection by human papillomavirus (HPV) may cause biological changes in the cervical epithelium, leading to VOC production.
methodsThis study included 200 urine samples from cervical cancer patients and controls that were HPV-negative. Urine samples were collected and measured using a gas sensor array composed of a matrix of 10 sensors. For each analyzed sample, the instrument produced a vector signal encoding the VOC emitted from the urine (urine prints). The urine prints of cervical cancer patients were differentiated from those of healthy controls.
resultsIdentification of VOC for cervical cancer detection showed reliable accuracy (91% sensitivity, 85% specificity, and 89% accuracy).
conclusionOur.
resultsdemonstrated the applicability of VOC sensing for cervical cancer detection and its potential application in treatment monitoring.
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