Evidence map›Paper›PMID 40592202›Full record

ArticlePsychiatry research2025

Sequenced psychotherapy improves evidence-based trauma-focused psychotherapy initiation and retention in a national sample of veterans.

William R Wolfe, Anna Staudenmeyer, Marylene Cloitre, Asale Hubbard, Martha Schmitz, Brian Mohlenhoff, Shira Maguen, Thomas C Neylan

Abstract read
In one paragraph

Article in Psychiatry research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

William R WolfeDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, 675 18th St., San Francisco, CA 94107, USA; San Francisco Veterans Affairs Health Care System, 4150 Clement St (116P), San Francisco, CA 94121, USA. Electronic address: william.wolfe@ucsf.edu.
Anna StaudenmeyerSan Francisco Veterans Affairs Health Care System, 4150 Clement St (116P), San Francisco, CA 94121, USA. Electronic address: anna.staudenmeyer@va.gov.
Marylene CloitreNew York University Silver School of Social Work, One Washington Square North, New York, NY 10003, USA. Electronic address: cloitm01@nyu.edu.
Asale HubbardDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, 675 18th St., San Francisco, CA 94107, USA; San Francisco Veterans Affairs Health Care System, 4150 Clement St (116P), San Francisco, CA 94121, USA. Electronic address: asale.hubbard@ucsf.edu.
Martha SchmitzDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, 675 18th St., San Francisco, CA 94107, USA; San Francisco Veterans Affairs Health Care System, 4150 Clement St (116P), San Francisco, CA 94121, USA. Electronic address: martha.schmitz@va.gov.
Brian MohlenhoffDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, 675 18th St., San Francisco, CA 94107, USA; San Francisco Veterans Affairs Health Care System, 4150 Clement St (116P), San Francisco, CA 94121, USA. Electronic address: brian.mohlenhoff@ucsf.edu.
Shira MaguenDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, 675 18th St., San Francisco, CA 94107, USA; San Francisco Veterans Affairs Health Care System, 4150 Clement St (116P), San Francisco, CA 94121, USA. Electronic address: shira.maguen@ucsf.edu.
Thomas C NeylanDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, 675 18th St., San Francisco, CA 94107, USA; San Francisco Veterans Affairs Health Care System, 4150 Clement St (116P), San Francisco, CA 94121, USA. Electronic address: thomas.neylan@ucsf.edu.

Funding

Clinical Features and Neuropathological Basis of Sleep Wake Behavior in Alzheimer's and PSPR01AG060477 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Lea Tenenholz Grinberg, Thomas C Neylan · 2019 to 2026
$8.2M
Investigating Fear System Myelination in PTSD Using In Vivo and Post Mortem DataR01MH132617 · NIMH · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI HUBER, BERTRAND R, NEYLAN, THOMAS C · 2023 to 2025
$2.1M
NIA NIH HHS R01 AG060477NIMH NIH HHS R01 MH132617
6 · The paper itself

Abstract

backgroundPosttraumatic stress disorder (PTSD) is a disabling condition costing the Veterans Administration (VA) $5 billion annually in disability compensation. Despite system-wide dissemination of Cognitive Processing Therapy (CPT) and Prolonged Exposure (PE) since 2007, only a small minority of veterans complete these treatments. We investigated the impact of sequenced treatment on initiation of and retention in CPT and PE across self-reported race and ethnicity, as well as recent heavy drinking and suicidal ideation (SI).

methodsVA administrative data were used to assess the impact of sequenced psychotherapy (SP), in which ≥ 8 sessions of non-trauma-focused individual (SPI) or group (SPG) psychotherapy was delivered before trauma-focused care, on initiation and retention in CPT and PE over two years from PTSD treatment initiation. Results were analyzed by self-reported race and ethnicity, heavy drinking (AUDIT-C ≥6), and SI (PHQ9 Q9>1).

resultsNationwide, 12.9 % of veterans who entered care for PTSD between 10/1/2014 and 11/30/2020 (n = 490,097) initiated VA-disseminated evidence-based treatment within 21 months (9.5 % CPT, 3.4 % PE). Among those, treatment retention (≥ 8 sessions) was 46.4 % and 42.3 %, respectively. SPI and SPG were associated with 0.4-6.8 % increases in CPT and PE initiation across racial/ethnic and risk groups. SPI was associated with increased CPT and PE retention of 8.0 % and 8.2 %; for SPG, retention increases were 3.4 % and 8.7 %. Strikingly, Hispanic White veterans with heavy drinking had 21.7 % increased CPT retention following SPG.

conclusionsSequential individual and group psychotherapy may improve initiation and completion of CPT and PE, particularly for certain minoritized and high-risk groups.

Indexed as

Cognitive Behavioral TherapyImplosive TherapyPsychotherapyPsychotherapy, GroupStress Disorders, Post-TraumaticVeteransAdultAgedFemaleHumansMaleMiddle AgedSuicidal IdeationUnited StatesUnited States Department of Veterans AffairsCognitive Processing TherapyPhase-Based PsychotherapyPosttraumatic Stress DisorderProlonged Exposure TherapyPsychotherapySequenced PsychotherapyVeterans Affairs

Identifiers

PMID40592202
PMCPMC12994157

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.