Evidence map›Paper›PMID 40592199›Full record

ArticleLung cancer (Amsterdam, Netherlands)2025

Nonagenarians: Outcomes after lung cancer surgery.

Hely Ollila, Amina Tidjani, Bernard J Park, David R Jones, Prasad S Adusumilli

Abstract read
In one paragraph

Article in Lung cancer (Amsterdam, Netherlands), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hely OllilaThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, United States. Electronic address: ollilah1@mskcc.org.
Amina TidjaniThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, United States. Electronic address: tidjana1@mskcc.org.
Bernard J ParkThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, United States. Electronic address: parkb@mskcc.org.
David R JonesThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, United States. Electronic address: jonesd2@mskcc.org.
Prasad S AdusumilliThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, United States. Electronic address: adusumip@mskcc.org.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
SURGICAL ONCOLOGY RESEARCH TRAINING PROGRAMT32CA009501 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Babak J Mehrara · 1985 to 2026
$7.7M
A phase I/II combination immunotherapy clinical trial: mesothelin-targeted chimeric antigen receptor T cells and checkpoint blockade agent in pleural mesotheliomaR01CA235667 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ADUSUMILLI, PRASAD S. · 2019 to 2024
$3.6M
Tuning KITv CAR T cells for the solid tumor environmentR01CA292664 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Prasad S. Adusumilli · 2024 to 2026
$3.2M
CD28-KITv CAR T cells with PD-1 dominant negative receptorUG3CA290241 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ADUSUMILLI, PRASAD S. · 2024 to 2025
$3.1M
Image-guided irreversible electroporation directed CAR T-cell delivery to solid tumorsR01CA236615 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ADUSUMILLI, PRASAD S., SOLOMON, STEPHEN BARNETT · 2018 to 2022
$2.0M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA235667NCI NIH HHS R01 CA236615NCI NIH HHS R01 CA292664NCI NIH HHS T32 CA009501NCI NIH HHS UG3 CA290241
6 · The paper itself

Abstract

introductionAn increasing number of nonagenarians are being referred to thoracic surgery clinics for the treatment of non-small cell lung cancer (NSCLC). However, discussions with the patient about surgical resection as a treatment option and the related informed consent process are constrained by the lack of specific information regarding perioperative and short- and long-term outcomes after surgery in this cohort of patients.

methodsWe retrospectively identified patients aged ≥90 years who underwent surgical resection for NSCLC at Memorial Sloan Kettering Cancer Center from 2001 to 2021. Risks, complications, and outcomes related to surgical treatment, including neurocognitive complications, length of stay, readmissions, mortality, and survival, were assessed.

resultsDuring the study period, 17 nonagenarian patients underwent surgical resection for NSCLC at our center; 15 of these patients (88%) received geriatric and/or cardiology consultation before surgery. Fourteen patients (82%) experienced minor complications; however, evidence of postoperative neurocognitive status compromise was not observed. Median length of stay was 5 days; 3 patients (18%) were readmitted within 90 days of discharge. No patients died within 30 or 90 days of surgical resection. Median overall survival was 43 months.

conclusionsOutcomes among nonagenarian patients who were selected to undergo surgical resection for NSCLC were positive, with overall survival approaching that of the general population of 90-year-olds. The data from this study can enrich the informed consent discussion with nonagenarian patients who are candidates for surgical resection for NSCLC.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsPneumonectomyPostoperative ComplicationsAged, 80 and overFemaleHumansLength of StayMaleRetrospective StudiesTreatment OutcomeLung cancer in older patientsLung cancer surgeryNon-small cell lung cancer

Identifiers

PMID40592199
PMCPMC12305799

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.