Evidence map›Paper›PMID 40591841›Full record

ArticleParasite (Paris, France)2025

Bioassay tests reveal for the first time pyrethroid resistance in Aedes mosquitoes from Franceville, southeast Gabon, Central Africa.

Judicaël Obame-Nkoghe, Faël Moudoumi Kondji, El Hadji Diouf, Omar Thiaw, Brad Ghaven Niangui, Arnauld Ondo-Oyono, Yasmine Okomo-Nguema, Neil Michel Longo-Pendy, Franck Mounioko, Boris Makanga and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasite (Paris, France), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Judicaël Obame-NkogheDépartement de Biologie de l'Université des Sciences et Techniques de Masuku (USTM), BP 901, Franceville, Gabon - Unité de Recherche en Ecologie de la Santé du Centre Interdisciplinaire de Recherches Médicales de Franceville (CIRMF), BP 769, Franceville, Gabon - Department of Zoology and Entomology, Faculty of Natural and Agricultural Sciences, University of the Free State, Phuthaditjhaba 9866, Republic of South Africa.ORCID 0000-0003-4301-7745
Faël Moudoumi KondjiDépartement de Biologie de l'Université des Sciences et Techniques de Masuku (USTM), BP 901, Franceville, Gabon.
El Hadji DioufLaboratoire d'Écologie Vectorielle et Parasitaire, Université Cheikh Anta Diop de Dakar, BP 5005 Dakar, Sénégal.
Omar ThiawLaboratoire d'Écologie Vectorielle et Parasitaire, Université Cheikh Anta Diop de Dakar, BP 5005 Dakar, Sénégal.
Brad Ghaven NianguiDépartement de Biologie de l'Université des Sciences et Techniques de Masuku (USTM), BP 901, Franceville, Gabon.
Arnauld Ondo-OyonoUnité de Recherche en Ecologie de la Santé du Centre Interdisciplinaire de Recherches Médicales de Franceville (CIRMF), BP 769, Franceville, Gabon.
Yasmine Okomo-NguemaUnité de Recherche en Ecologie de la Santé du Centre Interdisciplinaire de Recherches Médicales de Franceville (CIRMF), BP 769, Franceville, Gabon.
Neil Michel Longo-PendyUnité de Recherche en Ecologie de la Santé du Centre Interdisciplinaire de Recherches Médicales de Franceville (CIRMF), BP 769, Franceville, Gabon.
Franck MouniokoDépartement de Biologie de l'Université des Sciences et Techniques de Masuku (USTM), BP 901, Franceville, Gabon - Unité de Recherche en Ecologie de la Santé du Centre Interdisciplinaire de Recherches Médicales de Franceville (CIRMF), BP 769, Franceville, Gabon.
Boris MakangaResearch Institute in Tropical Ecology (IRET), BP 13354, Libreville, Gabon.
Basile KamgangCentre for Research in Infectious Diseases (CRID), PO Box 13591, Yaoundé, Cameroun.
Christophe PaupyMIVEGEC, Univ. Montpellier, CNRS, IRD, 34394 Montpellier, France.
Pierre KengneMIVEGEC, Univ. Montpellier, CNRS, IRD, 34394 Montpellier, France.
Patricks Voua OtomoDepartment of Zoology and Entomology, Faculty of Natural and Agricultural Sciences, University of the Free State, Phuthaditjhaba 9866, Republic of South Africa.
El Hadji Amadou NiangLaboratoire d'Écologie Vectorielle et Parasitaire, Université Cheikh Anta Diop de Dakar, BP 5005 Dakar, Sénégal.

Funding

The African Academy of Sciences ARISE-PP-FA-072
6 · The paper itself

Abstract

The spread of resistance to insecticides, such as pyrethroids, in Aedes vectors increases the risk of spread of arboviral diseases. In Gabon, the insecticide resistance profiles of Ae. aegypti and Ae. albopictus species remain poorly known. During a study to monitor the dynamics of Aedes populations in Franceville, in south-east Gabon, the resistance profiles of these two species to pyrethroids, organophosphates and carbamates were assessed. Susceptibility tests on adults and synergist tests with piperonyl butoxide (PBO) were carried out as per the World Health Organization protocol. The results showed that Ae. aegypti and Ae. albopictus were susceptible to permethrin, pirimiphos-methyl and bendiocarb. However, both species were resistant to deltamethrin (mortality: 67% for Ae. aegypti; 33% for Ae. albopictus). Exposure to a 5-fold dose of deltamethrin increased mortality to 100% and 91% for Ae. aegypti and Ae. albopictus, respectively. Resistance to alpha-cypermethrin was also recorded (mortality: 82% for Ae. aegypti; 64.6% for Ae. albopictus). Pre-exposure to PBO resulted in the restoration of susceptibility to deltamethrin and alpha-cypermethrin for Ae. aegypti, and a significant increase in mortality for Ae. albopictus. These data provide the first evidence of pyrethroid resistance in Aedes in Gabon and could help to establish more effective control measures against arbovirus vectors.

Indexed as

AedesInsecticide ResistanceInsecticidesMosquito VectorsPyrethrinsAnimalsBiological AssayFemaleGabonNitrilesOrganothiophosphorus CompoundsPermethrinPhenylcarbamatesPiperonyl ButoxidebendiocarbcypermethrindecamethrinInsecticidesNitrilesOrganothiophosphorus CompoundsPermethrinPhenylcarbamatesPiperonyl Butoxidepirimiphos methylPyrethrinsAedesCarbamatesInsecticide resistanceOrganophosphatesPBOPyrethroids

Identifiers

PMID40591841
PMCPMC12212768

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.