ArticlePloS one2025
Effects of a single bout of high-intensity-interval exercise on cardiovascular autonomic, cerebrovascular, and cognitive function in people with spinal cord injury: A study protocol.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06274658 (The Effects of an Acute High-intensity Interval Training on Heart and Brain Function in People With Spinal Cord Injury), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of an Acute High-intensity Interval Training on Heart and Brain Function in People With Spinal Cord Injury
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSpinal cord injury (SCI) frequently disrupts the autonomic nervous system (ANS), impairing cardiovascular function and affecting cerebrovascular and cognitive functions. While high-intensity interval exercise (HIIE) is known to improve cardiovascular and cognitive functions in non-injured populations, its impact on these functions in individuals with SCI, especially those with high-level injuries, is not well-documented.
objectiveThe primary aim of this study is to investigate the acute effects of a single bout of HIIE on ANS related-cardiovascular (ANS-CV) function in individuals with chronic SCI at or above T6. The secondary aims are to examine the acute effects of the same HIIE bout on cerebrovascular dynamics and cognitive performance in this population.
methodsIn this prospective case-control study, 15 individuals with SCI at T6 or above and 15 age- and sex-matched uninjured controls will be assessed. Measures include heart rate, heart rate variability, blood pressure, systolic blood pressure variability, cerebral blood flow velocities, and cognitive performance, analyzed pre- and post-HIIE. The sit-up test and face-cooling test will be used to activate the ANS-CV system. Post-exercise assessments will begin 5 minutes after completing the HIIE session. Cardiovascular testing will be conducted first and is expected to last 36 minutes. Cerebrovascular and cognitive testing will follow, starting approximately 41 minutes after the HIIE session. Covariates such as physical activity levels, pre-morbid intelligence, and psychological distress will be considered. This study has been approved by the University at Buffalo Institutional Review Board (IRB) (Approval Number: MOD00013354) and registered on ClinicalTrials.gov (Registration Number: NCT06274658).
resultsWe hypothesize that HIIE will improve cardiovascular and cerebrovascular functions and enhance cognitive performance in the SCI group. Data will be analyzed using linear mixed-effects models to evaluate the interaction effects of group and exercise.
conclusionsThis study is expected to fill the knowledge gap regarding the impact of HIIE on cardiovascular, cerebrovascular and cognitive functions in individuals with SCI at or above T6. The findings will provide crucial insights into immediate physiological responses while establishing foundational evidence for developing targeted, long-term exercise interventions to improve health outcomes in this population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.