Evidence map›Paper›PMID 40591563›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

UPF1 deficiency enhances mitochondrial ROS which promotes an immunosuppressive microenvironment in pancreatic ductal adenocarcinoma.

Wenjuan Su, Juan Kochen Rossi, Cristina Nuevo-Tapioles, Ting Chen, Emily Kawaler, Cristina Branco, Kwok-Kin Wong, Diane M Simeone, Lawrence B Gardner, Mark R Philips

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wenjuan Su *Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY 10016.ORCID 0000-0002-2398-5100
Juan Kochen Rossi *Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY 10016.ORCID 0000-0001-6452-0249
Cristina Nuevo-Tapioles *Perlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY 10016.ORCID 0000-0001-5809-2030
Ting ChenPerlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY 10016.
Emily KawalerPerlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY 10016.
Cristina BrancoPerlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY 10016.
Kwok-Kin WongPerlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY 10016.
Diane M SimeoneMoores Cancer Center, University of California, San Diego, CA 92037.
Lawrence B GardnerPerlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY 10016.
Mark R PhilipsPerlmutter Cancer Center, New York University Grossman School of Medicine, New York, NY 10016.ORCID 0000-0002-1179-8156

Funding

Differential function and tumor vulnerabilities revealed by RAS membrane traffickingR35CA253178 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 2020 to 2026
$6.8M
Role of nonsense mediated RNA decay in pancreatic cancerR01CA211687 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PHILIPS, MARK REID · 2018 to 2022
$2.1M
Characterization of the PKM2-RAS Interaction as a Novel Metabolic Vulnerability of RAS-driven TumorsF31CA261120 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KOCHEN ROSSI, JUAN ANDRES · 2021 to 2022
$76k
HHS | National Institutes of Health (NIH) F31CA261120HHS | National Institutes of Health (NIH) R01CA211687 R35CA253178NCI NIH HHS F31 CA261120NCI NIH HHS R01 CA211687NCI NIH HHS R35 CA253178
6 · The paper itself

Abstract

Upstream frameshift 1 (UPF1) is an RNA helicase involved in a number of mRNA regulatory processes including nonsense-mediated decay. Mutations in the

Indexed as

Carcinoma, Pancreatic DuctalMitochondriaPancreatic NeoplasmsReactive Oxygen SpeciesRNA HelicasesTrans-ActivatorsTumor MicroenvironmentAnimalsCell Line, TumorHumansMiceMice, Inbred C57BLReactive Oxygen SpeciesRNA HelicasesTrans-Activatorscomplex Imitochondrial ROSmyeloid-derived suppressor cellstumor microenvironmentUPF1

Identifiers

PMID40591563
PMCPMC11331118

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.