Evidence map›Paper›PMID 40591485›Full record

ArticleeLife2025

Cardiac fibroblasts regulate myocardium and coronary vasculature development in the murine heart via the collagen signaling pathway.

Yiting Deng, Yuanhang He, Juan Xu, Haoting He, Manling Zhang, Guang Li

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Elucidating Gene Functions in Congenital Heart Disease.Current treatment options in cardiovascular medicine · 2026
    Review
  9. Epicardium-myocardium crosstalk orchestrates heart development.Frontiers in cell and developmental biology · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Yiting Deng *Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States.
Yuanhang He *Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States.
Juan XuDepartment of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States.ORCID https://orcid.org/0009-0004-3184-8730
Haoting HeDepartment of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States.
Manling ZhangVascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, United States.
Guang LiDepartment of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States.ORCID https://orcid.org/0000-0002-8546-2364

Funding

Generation of four-chambered hearts through organoid fusionsDP2HL163745 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LI, GUANG · 2021 to 2024
$2.4M
Cellular and Molecular Mechanisms of Atrial Cardiomyocyte Lineage Commitment R00HL133472 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LI, GUANG · 2019 to 2021
$750k
Additional Ventures SVRF grantNHLBI NIH HHS DP2 HL163745NHLBI NIH HHS R00 HL133472NHLBI NIH HHS R00HL133472NIH Office of the Director DP2HL163745
6 · The paper itself

Abstract

The fibroblast (FB), cardiomyocyte (CM), and vascular endothelial cell (Vas_EC) are the three major cell types in the heart, yet their relationships during development are largely unexplored. To address this gap, we employed RNA staining of the FB marker gene

Indexed as

CollagenCoronary VesselsFibroblastsHeartMyocardiumMyocytes, CardiacSignal TransductionAnimalsEndothelial CellsMiceCollagenablationdevelopmental biologyextracellular matrixfibroblastheartmousemyocardiumsingle cell

Identifiers

PMID40591485
PMCPMC12212917

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.