Evidence map›Paper›PMID 40591234›Full record

ArticleMolecular diversity2026

Synthesis, molecular docking, molecular dynamic simulation and biological evaluation of novel 3,4-dihydropyridine derivatives as potent antituberculosis agents.

Riya Khandelwal, Mahesh Vasava, Vijay Kevlani, Chintan Parmar, Apurva Prajapati, Hitesh Patel, Paresh Patel

Abstract read
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In one paragraph

Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Riya KhandelwalSchool of Pharmacy, National Forensic Sciences University, Gandhinagar, Gujarat, India.
Mahesh VasavaSchool of Pharmacy, National Forensic Sciences University, Gandhinagar, Gujarat, India. mahesh.vasava@nfsu.ac.in.
Vijay KevlaniSchool of Pharmacy, National Forensic Sciences University, Gandhinagar, Gujarat, India.
Chintan ParmarSchool of Forensic Science, National Forensic Sciences University, Gandhinagar, Gujarat, India.
Apurva PrajapatiDepartment of Chemistry, School of Sciences, Gujarat University, Ahmedabad, Gujarat, India.
Hitesh PatelDepartment of Chemistry, School of Sciences, Gujarat University, Ahmedabad, Gujarat, India.
Paresh PatelDepartment of Pharmaceutical Chemistry, LJ Institute of Pharmacy, LJ University, Ahmedabad, Gujarat, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotic resistance is an increasing threat to global public health. Developing new antibiotics and alternative treatments is crucial for combating resistant strains and reducing the global health burden. Hence, we synthesized and evaluated the antitubercular potential of dihydropyridine derivatives. A simplified Biginelli condensation method was employed to synthesize novel 3,4-dihydropyrimidine derivatives (4a-4m) via a one-pot three-component reaction using various substituted benzaldehydes. Reaction completion was monitored via thin-layer chromatography. The structures of the compounds were confirmed by FT-IR, mass spectrometry,

Indexed as

Antitubercular AgentsDihydropyridinesMolecular Docking SimulationMolecular Dynamics SimulationChemistry Techniques, SyntheticMicrobial Sensitivity TestsMycobacterium tuberculosisStructure-Activity RelationshipAntitubercular AgentsDihydropyridinesAntibacterial activityAntitubercular activityBiginelli reactionDihydropyrimidine derivativesHeterocyclic compoundsMolecular docking

Identifiers

PMID40591234

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.