Evidence map›Paper›PMID 40591208›Full record

ArticleJournal of neuro-oncology2025

Anatomical distribution and prognostic heterogeneity in glioma: unique clinical features of occipital glioblastoma.

Chongshun Zhao, Bo Liang, Xiaopeng Li, Peiheng Ma, Yiming Li, Zenghui Qian, Zhong Zhang, Tao Jiang, Wei Zhang

Abstract read
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In one paragraph

Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chongshun Zhao *Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, PR China.
Bo Liang *Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100070, PR China.
Xiaopeng LiDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, PR China.
Peiheng MaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, PR China.
Yiming LiDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, PR China.
Zenghui QianDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, PR China.
Zhong ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, PR China.
Tao JiangDepartment of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100070, PR China. taojiang1964@163.com.
Wei ZhangDepartment of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100070, PR China. zhangwei_vincent@mail.ccmu.edu.cn.

Funding

Beijing Municipal Health Commission JYY2023-2Beijing Municipal Health Commission Research Ward Excellence Clinical Research Program BRWEP2024W032040202Dengfeng Talents Program of Beijing Hospitals Authority DFL20240503Foundation of Changzhou Xitaihu Institute for Frontier Technology of Cell Therapy 2022-P-019National Natural Science Foundation of China 82072768the Excellent Youth Talents Program of Capital Medical University A2205the Outstanding Young Scientist Program of Beijing Universities JWZQ20240101026the Public Welfare Development and Reform Pilot Project of Beijing Medical Research Institute 11000024T000003039585Yangfan Program of Beijing Hospitals Authority ZLRK202314Youth Beijing Scholar No. 055
6 · The paper itself

Abstract

backgroundAdult-type diffuse gliomas, particularly IDH-wildtype glioblastoma, exhibit significant differences in incidence across brain regions, with the occipital lobe being the rarest location. However, whether occipital glioblastoma differs from tumour in other regions in terms of prognosis and biological characteristics remains poorly understood.

methodsThis study included a total of 7,583 adult-type diffuse glioma patients from the SEER database, two public glioma datasets (UCSF-PDGM and UPENN-GBM), and a private dataset (Beijing Tiantan Hospital). For imaging data, Tumour location was classified using the USCLobes atlas, and white matter Tract Density Index (TDI) was computed to assess structural infiltration. Survival analyses employed Cox models and propensity score matching (PSM), adjusting for age, resection extent, and other confounders.

resultsThe occipital lobe was the least common location for adult-type diffuse glioma (p < 0.001). Multivariable analysis adjusting for extent of resection and other confounders demonstrated that occipital tumours retained a significant survival advantage (adjusted HR = 0.82, 95% CI: 0.69-0.97, p = 0.019), corroborated in PSM cohorts (median OS 14 vs. 13 months, p = 0.012) and validated across independent datasets (HR = 0.73, 95% CI: 0.55-0.97, p = 0.027). Occipital glioblastoma exhibited lower TDI (p < 0.001).

conclusionOccipital glioblastoma represents a distinct clinical entity associated with improved survival outcomes. This survival advantage may be attributed to reduced white matter tract infiltration. Future research should focus on the differences in biological characteristics and treatment strategies of gliomas at different locations.

Indexed as

Brain NeoplasmsGlioblastomaGliomaOccipital LobeAdultAgedFemaleHumansMaleMiddle AgedPrognosisYoung AdultGlioblastomaOccipital lobeSurvival analysisTract density indexTumour location

Identifiers

PMID40591208

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