ArticleEJNMMI physics2025
Quantitative whole-body dynamic planar scintigraphy in mice with
Article in EJNMMI physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundPlanar scintigraphy remains commonplace in clinical practice and has been used for quantification and dosimetry estimation over an expanding range of gamma-emitting radionuclides in recent years. Applications of planar scintigraphy, in combination with SPECT/CT imaging, can add value to radiopharmaceutical development in preclinical models and in translation to human use. The aim of this study was to demonstrate whole-body quantitative accuracy in mice using pinhole collimated planar scintigraphy on a preclinical SPECT/CT system, following corrections to sensitivity variations across the field of view.
resultsPlanar projections were acquired using short imaging time frames, thus allowing for dynamic biodistribution data to be collected and compared to the known injected activity and whole-body SPECT data. Encapsulation of [
conclusionsUsing a common radionuclide and one of emerging radiotherapeutic interest, whole-body injected activity and organ-specific ROI values obtained by planar scintigraphy strongly correlated to the true injected activity and values obtained by SPECT following sensitivity-based corrections. The addition of quantitative dynamic planar scintigraphy into the preclinical workflow followed by SPECT imaging adds value to pharmacokinetic and dosimetry assessments of novel gamma-emitting radiopharmaceuticals in imaging and therapeutic applications.
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