ArticleDiscover oncology2025
Comprehensive characterization of NK cell-related genes in cutaneous melanoma identified a novel prognostic signature for predicting the prognosis, immunotherapy, and chemotherapy efficacy.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
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- ACOT9, a mitochondrial metabolism-related gene, promotes ROS-associated epithelial remodeling in laryngeal squamous cell carcinoma.Journal of translational medicine · 2026Article
- Exploring epigenome-proteome interactions underlying post-surgical progression of non-functioning pituitary adenomas using hypernetwork modelling.Journal of translational medicine · 2026Article
- WBT-DC pipeline: a cross-cohort and cross-platform disease classification pipeline based on whole-blood transcriptomics.Journal of translational medicine · 2026Article
- An explainable multimodal machine learning model for diagnosing disorders of consciousness: evidence from a large multicenter Chinese cohort.Journal of translational medicine · 2026Observational
- Preoperative lymphocyte-albumin-monocyte index as an inflammation- and nutrition-based predictor of overall survival in triple-negative breast cancer: A retrospective cohort study.Oncology letters · 2026Article
- TMEM132A is associated with metabolic reprogramming, macrophage-oriented immune remodeling, and breast cancer progression.Clinical and experimental medicine · 2026Article
- Global Burden and Drivers of Cutaneous Malignant Melanoma Among Women Aged 55 and Older.International journal of women's health · 2026Article
- An anoikis-related four-gene prognostic signature and functional characterization of ANXA5 in laryngeal squamous cell carcinoma.Frontiers in immunology · 2026Article
- Burdens of Malignant Melanoma and Projections for 2050 in Asia: Findings from the 2023 Global Burden of Disease Study.Clinical, cosmetic and investigational dermatology · 2026Article
- Lactylation and tumor immune regulation: insights from recent studies.Frontiers in immunology · 2025Review
- Novel immune-nutritional prognostic ratio predicts long-term survival in stage I-III colorectal cancer.Frontiers in oncology · 2025Article
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6 authors.
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Abstract
backgroundNatural killer (NK) cells, as key effectors of the innate immune system, play a crucial role in cancer prognosis and immunotherapy. This study aimed to develop a predictive model based on NK cell-associated immune genes (NKIGs) for patients with cutaneous melanoma (CM) and to assess its utility in predicting prognosis and guiding personalized treatment.
methodsRNA-sequencing data and clinical information of CM patients were retrieved from The Cancer Genome Atlas (TCGA) database, while expression profiles from normal skin specimens were obtained from the Genotype-Tissue Expression (GTEx) database. Single-cell transcriptomes from CM were analyzed in conjunction with immune genes to identify NKIGs. These genes were then utilized to construct a prognostic model using univariate Cox regression and LASSO-Cox analysis. The model's accuracy and efficacy were evaluated through various statistical methods. Immunological characteristics, as well as the effectiveness of immunotherapy and chemotherapy in groups defined by the NKIGs signature, were explored. Additionally, the expression levels of NKIGs were validated via RT-qPCR in vitro experiments.
resultsThe overall survival (OS) of patients in the low-risk group, as determined by the NKIGs signature, was significantly better than the high-risk group. The low-risk group also showed higher immune cell infiltration, particularly of CD8 T cells and activated CD4 memory T cells.
conclusionsThis study has established a novel NKIGs signature with significant potential for predicting prognosis and guiding personalized therapeutic approaches in CM patients.
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