Observational studyJournal of patient-reported outcomes2025
Decline in quality of life among caregivers of patients undergoing chemotherapy for incurable cancer: implications for early social and medical support.
Observational study in Journal of patient-reported outcomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Association Between Health-Related Quality of Life In Patients with Colorectal Cancer and Their Informal Caregivers.Advances in therapy · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent advances in cancer treatment have extended patient survival and improved quality of life (QOL), often enabling home-based chemotherapy. However, this shift places a growing burden on informal caregivers, impacting their own well-being. This study aims to explore changes in caregiver QOL over the course of treatment and identify contributing factors.
methodsWe conducted a single-institution, prospective observational study involving patients receiving chemotherapy for unresectable or recurrent solid tumors and their primary caregivers. QOL was assessed using the EORTC QLQ-C30 before each treatment line. Scores were stratified by treatment duration and line. Paired t-tests and multiple linear regression analyses were performed.
resultsAmong 378 patient-caregiver pairs, caregiver emotional and cognitive functioning declined over time, particularly with longer treatment durations and later treatment lines. Fatigue prevalence increased to 100% by the fourth-line treatment. Regression analyses revealed that caregiver QOL was affected by patient symptoms (e.g., insomnia, appetite loss), patient QOL scores, treatment duration, and caregiver age and gender.
conclusionsCaregivers experienced progressive emotional and cognitive declines paralleling the patient's clinical trajectory. These findings highlight the necessity of early and comprehensive support systems for caregivers, including psychological and social support, to maintain their QOL throughout cancer treatment.
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