Evidence map›Paper›PMID 40591132›Full record

ReviewDiscover oncology2025

Ferulic acid as a promising candidate for developing selective and effective anti-cancer therapies.

Abdur Rauf, Rahaf Ajaj, Zuneera Akram, Nabia Hafeez, Maksim Rebezov, Mohammad Ali Shariati, Abdullah S M Aljohani, Muhammad Imran, Fahad Tanveer, Hassan A Hemeg and 1 more

Abstract readReview
In one paragraph

Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. International journal of molecular sciences · 2026
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Abdur RaufDepartment of Chemistry, University of Swabi, Anbar, 23561, Khyber Pakhtunkhwa, Pakistan. mashaljcs@yahoo.com.
Rahaf AjajDepartment of Environmental and Public Health, College of Health Sciences, Abu Dhabi University, Abu Dhabi, United Arab Emirates. r.ajaj@outlook.com.
Zuneera AkramDepartment of Pharmacology, Faculty of Pharmaceutical Sciences, Baqai Medical University, Karachi, Pakistan.
Nabia HafeezCentre of Biotechnology & Microbiology, University of Peshawar, Peshawar, Pakistan.
Maksim RebezovDepartment of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, 26 Talalikhin Str., Moscow, 109316, Russia.
Mohammad Ali ShariatiSemey Branch of the Kazakh Research Institute of Processing and Food Industry, Gagarin Avenue 238G, Almaty, 050060, Kazakhstan.
Abdullah S M AljohaniDepartment of Medical Biosciences, College of Veterinary Medicine, Qassim University, Buraydah, Saudi Arabia.
Muhammad ImranDepartment of Food Science and Technology, University of Narowal, Lahore, Pakistan.
Fahad TanveerDepartment of Rehabilitation Sciences, Green International University, Lahore, Pakistan.
Hassan A HemegDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taibah University, Al-Madinah Al-Monawara, Saudi Arabia.
Mohammad S MubarakDepartment of Chemistry, The University of Jordan, Amman, 11942, Jordan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCancer, a complex and rapidly advancing disease, stands as the second leading cause of death globally. Among the most frequently diagnosed cancers are breast, colon, lung, and prostate cancers. The incidence of these cancers has been rising sharply, a trend attributed partly to the insufficient effectiveness of current therapeutic drugs. This growing challenge has intensified the search for novel anti-cancer agents derived from natural sources.

methodsThis review covers the most recent literature on FA's anti-cancer properties. It provides an in-depth analysis of ferulic acid's impact on various cancer cell lines and the mechanisms of action.

resultsPlants are a rich reservoir of bioactive compounds that offer promising alternatives to synthetic drugs. Among these compounds, alkaloids, flavonoids, stilbenes, curcuminoids, and other phenolic substances have demonstrated significant free radical scavenging activity, suggesting their potential in various therapeutic applications. Ferulic acid (FA) is a hydroxycinnamic acid and phenolic compound found in different plants, fruits, vegetables, and grains. It occurs in exceptionally high concentrations in popcorn and bamboo shoots.

conclusionFA exhibits remarkable anti-inflammatory, antioxidant, and anti-cancer properties.

Indexed as

Anti-cancer potencyAnti-inflammatoryAntioxidantFreulic acidPhenols

Identifiers

PMID40591132
PMCPMC12214087

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.