Evidence map›Paper›PMID 40591074›Full record

ArticleInternational ophthalmology2025

Cyclocryotherapy applied at the 3 o'clock and 9 o'clock positions combined with anti-VEGF injections for advanced neovascular glaucoma.

Zijing Huang, Dingguo Huang, Jing Sheng Yi, Biyao Xie, Yifan Wang, Dezhi Zheng, Danqi Fang, Weiqi Chen

Abstract read
PubMed Publisher
In one paragraph

Article in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Anti-vascular endothelial growth factor therapies in ophthalmology.Medical hypothesis, discovery & innovation ophthalmology journal · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zijing HuangJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China.
Dingguo HuangJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China.
Jing Sheng YiJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China.
Biyao XieJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China.
Yifan WangJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China.
Dezhi ZhengJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China.
Danqi FangDepartment of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Weiqi ChenJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, China. cwq@jsiec.org.

Funding

Funding from the Shantou Science and Technology Plan Project 221113086496943
6 · The paper itself

Abstract

objectiveThis study aimed to investigate the efficacy of cyclocryotherapy applied at the 3 o'clock and 9 o'clock positions in combination with intravitreal anti-vascular endothelial growth factor (VEGF) injections in patients with advanced neovascular glaucoma (NVG).

methodsMedical records of patients diagnosed with NVG who underwent cyclocryotherapy at the 3 o'clock and 9 o'clock positions combined with intravitreal anti-VEGF injections between January 2021 and January 2023 were retrospectively reviewed. Baseline and follow-up data including intraocular pressure (IOP), best-corrected visual acuity, perioperative pain scores using numeric rating scale, intraocular cytokines levels, and surgical complications, were analyzed. A successful surgical outcome was defined as an IOP below 21 mmHg with at least a 30% reduction from baseline.

resultsA total of 20 eyes from 20 patients were included. Elevated levels of several inflammatory mediators and angiogenic cytokines were detected in aqueous and vitreous samples. Pain scores significantly decreased scores at one month postoperatively (0.5±0.9) compared to preoperative values (6.2±3.0) (P<0.001). At the 3-month follow up, the mean IOP was 26.4±15.9 mmHg, representing a 39.0% reduction from baseline (43.2±10.6 mmHg) (P=0.003). At the final follow-up visit (mean duration 13.3±4.5 months), the mean IOP was 26.6±15.2 mmHg, corresponding to a 38.4% reduction from baseline. No cases of anterior segment ischemia or phthisis bulbi were documented during the follow-up period. The surgical success rate was 55% at 3 months and 60% at the final follow-up.

conclusionsCyclocryotherapy applied at the 3 o'clock and 9 o'clock position combined with anti-VEGF treatment presents a potential treatment alternative for advanced NVG. Further research is needed to validate its long-term efficacy and safety profile.

Indexed as

Angiogenesis InhibitorsBevacizumabCiliary BodyGlaucoma, NeovascularIntraocular PressureRanibizumabAgedCombined Modality TherapyFemaleFollow-Up StudiesHumansIntravitreal InjectionsMaleMiddle AgedRetrospective StudiesTreatment OutcomeAngiogenesis InhibitorsBevacizumabRanibizumabVascular Endothelial Growth Factor A3 o’clock and 9 o’clockAnti-VEGFCombination therapyCyclocryotherapyNeovascular glaucoma

Identifiers

PMID40591074

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.