Evidence map›Paper›PMID 40591065›Full record

ReviewAdvanced biotechnology2025

Microalgae-driven microrobots: revolutionizing drug delivery and targeted therapy in biopharmaceuticals.

Xianmin Wang, Songlin Ma, Renwu Liu, Tiexin Zhang, Xinyu Mao, Yuxue Chen, Pengcheng Wan, Zhanyou Chi, Fantao Kong

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Light force-powered cellular medical micromachines.Frontiers in bioengineering and biotechnology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xianmin Wang *MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, DalianLiaoning, 116024, China.
Songlin Ma *MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, DalianLiaoning, 116024, China.
Renwu Liu *Central Hospital of Dalian University of Technology, Dalian Municipal Central Hospital, DalianLiaoning, 116000, China.
Tiexin ZhangState Key Laboratory of Fine Chemicals, School of Chemical Engineering, School of Chemistry, Dalian University of Technology, Dalian, 116024, China.
Xinyu MaoMOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, DalianLiaoning, 116024, China.
Yuxue ChenMOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, DalianLiaoning, 116024, China.
Pengcheng WanMOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, DalianLiaoning, 116024, China.
Zhanyou ChiMOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, DalianLiaoning, 116024, China.
Fantao KongMOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, DalianLiaoning, 116024, China. kongfantao@dlut.edu.cn.ORCID http://orcid.org/0000-0003-2847-2838

Funding

Dalian Municipal Health and Wellness Guidance Plan Project 2023ZXYG22Fundamental Research Funds for the Central Universities DUT24BK033Fundamental Research Funds for the Central Universities DUT25Z2505Natural Science Foundation of Liaoning Province 2024-MSLH-062
6 · The paper itself

Abstract

Microalgae are a group of photosynthetic autotrophic microorganisms that are classified as Generally Recognized as safe (GRAS). They are rich in high-value bioactive compounds with broad applications in food, healthcare and pharmaceuticals. Recent research demonstrated that microalgae have significant potential as innovative biomaterials for biomedical applications. The unique phototactic movement of microalgae enables them controlled drug delivery to targeted tissues in patients. Furthermore, microalgae produce oxygen via photosynthesis when exposed to light, overcoming tumor hypoxia limitations and improving biomedical imaging in vivo. Additionally, the intrinsic biophysical properties and modifiability of microalgae can be harnessed for the development of biohybrid robots and bioprinting, expanding their clinical applications. This review highlights current engineering innovations in microalgae for medical applications, such as drug delivery, tumor hypoxia targeting, wound healing, and immunotherapy. The remarkable biocompatibility, diverse biological functionalities, and cost-effectiveness of microalgae provide a promising platform for future application of targeted drug delivery and precision medicine.

Indexed as

3D bioprintingBiopharmaceuticalsDrug deliveryMicroalgaeTargeted therapy

Identifiers

PMID40591065
PMCPMC12214163

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.