Evidence map›Paper›PMID 40591062›Full record

ArticleWorld journal of microbiology & biotechnology2025

Magnetic nanoparticle-based method for microorganism concentration in sterile body fluids: Validation and clinical applications.

Bilsen Tural, Erdal Ertaş, Nurullah Uzuner, Buşra Bektaş, Emre Tural, Mehmet Çavdar, Hakan Temiz, Erdal Özbek, Servet Tural

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of microbiology & biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bilsen TuralDepartment of Nanotechnology, Institute of Science, Dicle University, 21280, Diyarbakir, Turkey. btural@dicle.edu.tr.
Erdal ErtaşDepartment of Chemistry, Institute of Science, Dicle University, 21280, Diyarbakir, Turkey.
Nurullah Uzuner25 Aralık State Hospital Şehitkamil, Gaziantep, Turkey.
Buşra BektaşDepartment of Nanotechnology, Institute of Science, Dicle University, 21280, Diyarbakir, Turkey.
Emre TuralFaculty of Medicine, Department of Child Health and Diseases, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Mehmet ÇavdarDepartment of Medical Microbiology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
Hakan TemizDepartment of Medical Microbiology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
Erdal ÖzbekDepartment of Medical Microbiology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
Servet TuralDepartment of Nanotechnology, Institute of Science, Dicle University, 21280, Diyarbakir, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rapid and accurate detection of microorganisms in sterile body fluids, particularly cerebrospinal fluid (CSF), is crucial for effective diagnosis and treatment. Conventional methods, such as centrifugation, may result in low microbial recovery and false negatives, limiting diagnostic accuracy. An alternative, efficient, and accessible microbial concentration method is needed. This study evaluates a nanoparticle-based microbial concentration method to enhance pathogen recovery from CSF. The method was optimized for interaction time (1 min) and nanoparticle dosage (0.01 g/mL) using standard microbial strains, including Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans. Its clinical performance was assessed using 800 CSF samples, and microbial identification was confirmed via MALDI-TOF MS. The method significantly improved microbial recovery across 10

Indexed as

BacteriaBody FluidsCerebrospinal FluidMagnetite NanoparticlesCandida albicansCentrifugationEnterococcus faecalisHumansLimit of DetectionPseudomonas aeruginosaSensitivity and SpecificitySpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationStaphylococcus aureusMagnetite NanoparticlesCerebrospinal fluid diagnosticsClinical microbiologyDetection sensitivityLow-density microorganismsMagnetic nanoparticlesMicrobial detection

Identifiers

PMID40591062
PMCPMC12213996

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.