Evidence map›Paper›PMID 40591044›Full record

ArticleDiscover oncology2025

Pan-cancer analysis of the impact of fatty acids: a two-sample and multivariable Mendelian randomization study.

Xiaogen Kuang, Bingquan Wu, Dan Hu, Juliet Matsika, Chunliang Cheng, Jiatong Xiao, Zhiyong Cai, Mingyong Li, Jinbo Chen, Weimin Zhou and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaogen Kuang *Departments of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Bingquan Wu *Departments of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Dan HuDepartment of Urology, Liuyang Jili Hospital, Liuyang City, Hunan, China.
Juliet MatsikaDepartments of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chunliang ChengDepartments of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jiatong XiaoDepartments of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhiyong CaiDepartments of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Mingyong LiDepartment of Urology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Jinbo ChenDepartments of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Weimin ZhouDepartments of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, China. zhouwm0223@163.com.
Bolong LiuDepartment of Andrology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China. zndxlbl@csu.edu.cn.

Funding

National Natural Science Foundation of China 82373337Natural Science Foundation of Hunan Province 2023JJ30870
6 · The paper itself

Abstract

backgroundThis study used Mendelian randomization (MR) to investigate the causal association between circulating fatty acids (FAs) and the incidence of 10 human cancer types.

methodsSingle nucleotide polymorphisms (SNPs) significantly associated with circulating FAs were selected from 500,000 UK Biobank blood samples and 114,999 plasma samples from a large GWAS. Summary-level data on 174,006 cancer patients were obtained from the FinnGen biobank. The inverse variance weighted method was used for causal estimation, with additional analyses including MR-Egger regression, weighted median, weighted mode, Cochrane Q test, MR-PRESSO global test, and leave-one-out analyses. Multivariable Mendelian randomization (MVMR) was applied to adjust for potential confounders.

resultThis study found a genetically causal effect of polyunsaturated FAs on kidney cancer incidence (OR: 1.528; 95% CI 1.164-2.266; P = 0.001), which remained significant after Bonferroni adjustment. The causal impact of omega-6, omega-3, and linoleic acid on kidney cancer risk was also observed (omega-6: OR = 1.586, P = 0.002; omega-3: OR = 1.311, P = 0.014; linoleic acid: OR = 1.527, P = 0.007). MVMR confirmed the consistent causal relationship (OR = 1.553, P = 0.0047) after adjusting for multiple variables. Results were validated in a larger cohort.

conclusionsHigher circulating polyunsaturated FAs, especially omega-6, were associated with an increased risk of kidney cancer. Suggestive associations were found in small cell lung, rectal, bladder, pancreatic, and esophageal cancer.

Indexed as

Kidney cancerMendelian randomizationPan cancer analysisSaturated fatty acidUnsaturated fatty acid

Identifiers

PMID40591044
PMCPMC12214094

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.