Evidence map›Paper›PMID 40591025›Full record

ArticleCell biology and toxicology2025

YTHDF1 promotes p53 translation and induces ferroptosis during acute cerebral ischemia/reperfusion through m

Xinyu Chang, Bingwu Li, Wanxu Huang, Aixia Chen, Shengmin Zhu, Yueyang Liu, Xiaoling Liu, Jingyu Yang, Dan Ohtan Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell biology and toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. [Gastrodin alleviates hypobaric hypoxia-induced brain injury in rats by reducing neuronal ferroptosisNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
    Article
  2. mRedox biology · 2026
    Review
  3. mFrontiers in cell and developmental biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xinyu ChangWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, PR China.
Bingwu LiWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, PR China.
Wanxu HuangWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, PR China.
Aixia ChenWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, PR China.
Shengmin ZhuWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, PR China.
Yueyang LiuWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, PR China.
Xiaoling LiuWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, PR China. lxl91321@126.com.
Jingyu YangDepartment of Pharmacology, Shenyang Pharmaceutical University, Shenyang, PR China. yangjingyu@syphu.edu.cn.
Dan Ohtan WangWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, PR China. ohtan.wang@nyu.edu.

Funding

National Nature Science Foundation of China 31971335the National Nature Science Foundation of China 82104260
6 · The paper itself

Abstract

The rapid escalation of oxidative and nitrosative stress during ischemia/reperfusion (I/R) triggers neuronal damage, leading to severe neurological deficits and long-term disability. N6-methyladenosine (m

Indexed as

Brain InjuriesFerroptosisNerve Tissue ProteinsReperfusion InjuryRNA MethylationRNA Splicing FactorsTumor Suppressor Protein p53Acute DiseaseAnimalsCell LineMaleMiceOxidative StressProtein BindingProtein BiosynthesisNerve Tissue ProteinsRNA Splicing FactorsTrp53 protein, mouseTumor Suppressor Protein p53YTHDC1 protein, mouseFerroptosisI/R injurym6Ap53TranslationYTHDF1

Identifiers

PMID40591025
PMCPMC12213927

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.