ReviewArchives of microbiology2025
Regulation and induction of fungal secondary metabolites: a comprehensive review.
Review in Archives of microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Ibotenic Acid and Muscimol inMolecules (Basel, Switzerland) · 2026Review
- Low Nitrogen Concentration and Acidic pH Enhance the Antifungal Activity AgainstMicroorganisms · 2026Article
- Gold nanoparticle-mediated metabolic engineering in Trichoderma longibrachiatum MD33 unveils a hybrid terpenoid-alkaloid pathway for enhanced dendrobine biosynthesis.Microbial cell factories · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fungal secondary metabolites (SMs) represent a vast reservoir of bioactive compounds with immense therapeutic, agricultural, and industrial potential. These small molecules, including antibiotics, immunosuppressants, and anticancer agents, are synthesized through dedicated biosynthetic gene clusters (BGCs) regulated by various epigenetic, transcriptional, and environmental mechanisms. However, their cryptic biosynthesis and low natural yields pose significant challenges for large-scale production. This review comprehensively analyzes the regulatory landscape governing fungal SMs biosynthesis, advanced OMICS-driven approaches for identification of cryptic BGCs, and significantly emphasizes strategies to enhance SMs production. Furthermore, the integration of statistical and computational models (e.g., response surface methodology, artificial neural networks) is discussed for optimizing fermentation processes. The review underscores the diverse applications of fungal SMs in pharmaceuticals, agriculture, and cosmetics, while advocating for interdisciplinary innovations in synthetic biology and AI-driven metabolic engineering to sustainably harness fungal biodiversity.
Indexed as
Identifiers
40590991What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.