Evidence map›Paper›PMID 40590962›Full record

ArticleSkeletal radiology2025

Assessment of vastus medialis muscle quality in knee osteoarthritis using ultrashort echo time magnetization transfer MR imaging.

Mahyar Daskareh, Melissa Lou Silva, Hamidreza Shaterian Mohammadi, Arya Suprana, Dina Moazamian, Saeed Jerban, Yajun Ma

Abstract read
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In one paragraph

Article in Skeletal radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Mahyar DaskarehDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA.
Melissa Lou SilvaDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA.
Hamidreza Shaterian MohammadiDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA.
Arya SupranaDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA.
Dina MoazamianDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA.
Saeed JerbanDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA.
Yajun MaDepartment of Radiology, University of California, San Diego, La Jolla, CA, USA. yam013@ucsd.edu.

Funding

Ultrashort Echo Time Magnetic Resonance Imaging of the Lumbar Intervertebral Disc.R01AR079484 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Yajun Ma · 2022 to 2026
$2.7M
Knee evaluation under mechanical loading by cones ultrashort echo time MR imagingK01AR080257 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI saeed jerban · 2022 to 2026
$602k
Foundation for the National Institutes of Health K01AR080257Foundation for the National Institutes of Health K01AR080257&R01AR079484Foundation for the National Institutes of Health R01AR079484NIAMS NIH HHS K01 AR080257NIAMS NIH HHS R01 AR079484
6 · The paper itself

Abstract

objectivesKnee osteoarthritis (KOA) is a leading cause of disability, driven by cartilage degeneration, joint inflammation, and biomechanical stress. Beyond these changes, quadriceps muscle (QM) degradation, particularly in the vastus medialis (VM), has emerged as a key contributor to symptomatic KOA. Clinical MRI primarily offers qualitative assessments of muscle alterations, with limited ability to evaluate compositional changes, especially in collagen content. Novel ultrashort echo time magnetization transfer (UTE-MT) is a quantitative technique that can be used to evaluate muscle in KOA. MATERIALS AND

methodsThis cross-sectional study included 54 participants (mean age: 53 ± 17 years), comprising healthy volunteers and patients with knee osteoarthritis (KOA). Knee MRI was performed to map the magnetization transfer ratio (MTR) of the VM. Intramuscular fat infiltration was classified using the Goutallier score (GS). The performance of UTE-MTR was compared with that of the GS assessed on T1-weighted imaging (T1WI) and with UTE-T1 and UTE-T2* measurements. Correlation analysis was applied to assess the relationship between VM MRI biomarkers and KOA severity, classified according to the Kellgren-Lawrence (KL) grading. An ordinal regression model was designed to estimate the severity of KOA based on UTE-derived measurements.

resultsUTE-MTR of the VM demonstrated a strong negative correlation with KL groups (r =  - 0.82), outperforming T1WI (r = 0.55) for GS classification, as well as UTE-T1 (r =  - 0.60) and UTE-T2* (r =  - 0.50) techniques. The ordinal regression model identified UTE-MTR as the only statistically significant indicator of OA severity (adjusted odds ratio: 0.13).

conclusionsUTE-MTR is a promising quantitative imaging biomarker for assessing VM muscle degradation in KOA.

Indexed as

Magnetic Resonance ImagingOsteoarthritis, KneeQuadriceps MuscleAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedSeverity of Illness IndexCollagenKnee osteoarthritisMagnetization transferUltrashort echo time

Identifiers

PMID40590962
PMCPMC12782806

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.