Evidence map›Paper›PMID 40590947›Full record

ArticleEuropean journal of applied physiology2025

Probing gait adaptations: The impact of aging on dynamic stability and reflex control mechanisms under varied weight-bearing conditions.

Michelle Gwerder, Ursina Camenzind, Samira Wild, Yong K Kim, William R Taylor, Navrag B Singh

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Article in European journal of applied physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michelle GwerderLaboratory for Movement Biomechanics, Department of Health Sciences and Technology, ETH Zürich, Gloriastrasse 37/39, 8092, Zurich, ZH, Switzerland. michelle.gwerder@hest.ethz.ch.ORCID http://orcid.org/0000-0003-4484-9244
Ursina CamenzindLaboratory for Movement Biomechanics, Department of Health Sciences and Technology, ETH Zürich, Gloriastrasse 37/39, 8092, Zurich, ZH, Switzerland.
Samira WildLaboratory for Movement Biomechanics, Department of Health Sciences and Technology, ETH Zürich, Gloriastrasse 37/39, 8092, Zurich, ZH, Switzerland.
Yong K KimLaboratory for Movement Biomechanics, Department of Health Sciences and Technology, ETH Zürich, Gloriastrasse 37/39, 8092, Zurich, ZH, Switzerland.
William R TaylorLaboratory for Movement Biomechanics, Department of Health Sciences and Technology, ETH Zürich, Gloriastrasse 37/39, 8092, Zurich, ZH, Switzerland.
Navrag B SinghLaboratory for Movement Biomechanics, Department of Health Sciences and Technology, ETH Zürich, Gloriastrasse 37/39, 8092, Zurich, ZH, Switzerland.

Funding

Innosuisse - Schweizerische Agentur für Innovationsförderung 44964.1 IP-LSSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 32003B_200903/1
6 · The paper itself

Abstract

purposeMaintaining stable gait patterns is essential for preserving health and well-being throughout the aging process. While several biomechanical models have been developed to describe gait adaptation and stability, the role of reflex control mechanisms remains underexplored. This study aimed to understand the mechanisms by which disturbances to gait patterns (changes to weight-bearing conditions) are influencing gait adaptations, gait variability, and their underlying reflex control mechanisms during treadmill walking in young and older adults.

methodsTwenty young (mean age 25.7 ± 3.3 years) and 20 older adults (62.3 ± 4.3 years) walked on a treadmill under five weight-bearing conditions: normal bodyweight, 20 and 40% additional weight (bodyweight loading), and 20 and 40% reduced weight (bodyweight unloading). Linear mixed-effects models were used to assess spatiotemporal gait parameters, margin of stability, gait variability (standard deviation), and H-reflex amplitudes.

resultsBodyweight unloading significantly reduced antero-posterior margin of stability (p < 0.01). Compared to young adults, older adults exhibited shorter stride length, longer double-limb support time, larger antero-posterior margin of stability, and increased variability (p < 0.05). While H-reflex amplitudes increased with increasing weight-bearing in young adults, older adults were less capable to modulate their H-reflex amplitude across weight conditions.

conclusionThese findings suggest that gait adaptations under altered weight-bearing conditions involve shifts in temporal gait regulation and gait strategies. The reduced H-reflex modulation in older adults may indicate a limited ability to adapt spinal-level reflex amplitudes, leading to greater reliance on other balance control mechanisms. Understanding these neuromuscular adaptations is essential for designing prevention programs to enhance stability and prevent falls.

Indexed as

Adaptation, PhysiologicalAgingGaitH-ReflexWeight-BearingAdultAgedBiomechanical PhenomenaFemaleHumansMaleMiddle AgedPostural BalanceWalkingYoung AdultAgingDynamic stabilityGait adaptationGait variabilityReflex control mechanisms

Identifiers

PMID40590947
PMCPMC12678455

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.