Evidence map›Paper›PMID 40590903›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

Biodistribution of free Francium-221 and Bismuth-213 in Tumour-bearing SCID mice after successful development of Actinium-225/Francium-221 radionuclide generator Set-up.

Sabine Zitzmann-Kolbe, Yvonne Remde, Ingrid Moen, Balázs Madas, László Mázik, Frans Suurs, Steffen Happel, Martin Schäfer, Christoph Schatz, Harun Taş and 2 more

Abstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. α-Therapy and Combination Strategies to Overcome Resistance and Enhance Clinical Outcomes in Prostate Cancer.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sabine Zitzmann-KolbeBayer AG, Berlin, Germany.ORCID 0000-0002-1476-6299
Yvonne RemdeService Unit for Radiopharmaceuticals and Preclinical Studies, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany.
Ingrid MoenBayer AS, Oslo, Norway.ORCID 0000-0001-9814-9644
Balázs MadasEnvironmental Physics Department, Institute for Energy Security and Environmental Safety, HUN-REN Centre for Energy Research, Konkoly-Thege Miklós út 29-33, Budapest, 1121, Hungary.ORCID 0000-0002-0698-4982
László MázikEnvironmental Physics Department, Institute for Energy Security and Environmental Safety, HUN-REN Centre for Energy Research, Konkoly-Thege Miklós út 29-33, Budapest, 1121, Hungary.
Frans SuursBayer AS, Oslo, Norway.
Steffen HappelTrisKem International, 3 rue des Champs Geons, Bruz, 35170, France.ORCID 0000-0003-3567-9415
Martin SchäferService Unit for Radiopharmaceuticals and Preclinical Studies, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany.
Christoph SchatzBayer AG, Berlin, Germany.ORCID 0000-0001-8017-3400
Harun TaşResearch Group Translational Radiotheranostics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany.ORCID 0000-0002-1586-5360
Urs B HagemannBayer AG, Berlin, Germany.ORCID 0009-0003-6509-0844
Martina Benešová-SchäferResearch Group Translational Radiotheranostics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany. m.benesova@dkfz-heidelberg.de.ORCID 0000-0002-8926-5376

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDespite the clinical evidence of actinium-225 (

methodsThe immobilization of

resultsOur results indicate that LN2 resin is a highly efficient resin for selective separation of

conclusionWe present an unprecedented concept utilizing LN2 resin in

Indexed as

ActiniumBismuthRadioisotopesAnimalsCell Line, TumorHumansMaleMiceMice, SCIDRadiochemistryTissue DistributionActiniumActinium-225BismuthBismuth-213RadioisotopesActinium-225Bismuth-213Francium-221Radionuclide generatorsRadionuclide-specific organ accumulationTargeted alpha therapies

Identifiers

PMID40590903
PMCPMC12660422

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.