ArticleBiomarkers in medicine2025
Serum Ang 1, Ang 1-7, and Mas levels as potential biomarkers in obstructive sleep apnea syndrome.
Article in Biomarkers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimsIn obstructive sleep apnea (OSA), the balance between inflammatory and anti-inflammatory responses is disrupted. This study examined the association between serum angiotensin 1 (Ang 1), angiotensin 1-7 (Ang 1-7), and Mas receptor levels and OSA severity. MATERIAL AND
methodsA total of 190 subjects underwent polysomnography and serum analysis for Ang 1, Ang 1-7, and Mas using ELISA. Patients were classified into control, mild, moderate, and severe OSA groups based on AHI.
resultsAng 1-7, Ang 1, and serum Mas levels were significantly lower in moderate and severe OSA groups compared to control and mild OSA (
conclusionReduced levels of Ang 1-7, Ang 1, and Mas are associated with increased OSA severity. These biomarkers demonstrated high diagnostic value and may be useful in stratifying patients with moderate-to-severe OSA.
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