Evidence map›Paper›PMID 40590796›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2025

Effect of pre-exercise dietary nitrate on skeletal muscle blood flow in a rat model of pulmonary hypertension.

Gary Marshall Long, Ashley D Giourdas, Amanda J Fisher, Tim Lahm, Andrew R Coggan, Mary Beth Brown

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gary Marshall LongSchool of Health & Human Sciences, Indiana University, Indianapolis, Indiana, United States.ORCID 0000-0001-7682-3693
Ashley D GiourdasDivision of Nephrology and Hypertension, Indiana University, Indianapolis, Indiana, United States.ORCID 0000-0003-0217-949X
Amanda J FisherDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, Indiana University, Indianapolis, Indiana, United States.
Tim LahmDivision of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, Colorado, United States.ORCID 0000-0003-0007-6606
Andrew R CogganSchool of Health & Human Sciences, Indiana University, Indianapolis, Indiana, United States.ORCID 0000-0002-7723-8872
Mary Beth BrownDepartment of Rehabilitation Medicine, University of Washington, Seattle, Washington, United States.ORCID 0000-0003-4229-6877

Funding

The Inorganic Nitrate and eXercise performance in Heart Failure (iNIX-HF): - a phase II clinical trialR33HL155858 · NHLBI · WASHINGTON UNIVERSITY · PI ANDREW R COGGAN, LINDA Ruth PETERSON · 2023 to 2026
$2.9M
Maximizing benefit and minimizing detriment of exercise for pulmonary hypertensionR15HL121661 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI BROWN, MARY BETH · 2015 to 2015
$455k
NHLBI NIH HHS R15 HL121661NHLBI NIH HHS R33 HL155858
6 · The paper itself

Abstract

Skeletal muscle dysfunction contributes to exercise intolerance in patients with pulmonary arterial hypertension (PAH). Reduced blood flow to skeletal muscle has been demonstrated in a rat model of the disease. We investigated the effect of acute nitrate ([Formula: see text]) ingestion via beetroot juice (BRJ) on exercising muscle blood flow, and on plasma and muscle nitrate ([Formula: see text]), nitrite ([Formula: see text]), and cyclic GMP (cGMP) in male Sprague Dawley rats (∼200 g,

Indexed as

Fruit and Vegetable JuicesHypertension, PulmonaryMuscle, SkeletalNitratesPhysical Conditioning, AnimalAnimalsBeta vulgarisCyclic GMPDisease Models, AnimalMaleRatsRats, Sprague-DawleyRegional Blood FlowCyclic GMPNitratesexercisenitratepulmonary hypertensionskeletal muscle

Identifiers

PMID40590796
PMCPMC13296940

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.