Evidence map›Paper›PMID 40590786›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2025

Low tidal volume ventilation facilitates spontaneous increase in bronchoconstriction and air trapping that can be resolved by deep inspiration and bronchodilator.

Yuto Yasuda, Geoffrey N Maksym, Lu Wang, Pasquale Chitano, Chun Y Seow

Abstract read
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In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The value of deep inspirations.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Yuto YasudaCentre for Heart Lung Innovation, St. Paul's Hospital, Providence Health Care, University of British Columbia, Vancouver, British Columbia, Canada.
Geoffrey N MaksymSchool of Biomedical Engineering, Dalhousie University, Halifax, Nova Scotia, Canada.ORCID 0000-0003-4686-7059
Lu WangCentre for Heart Lung Innovation, St. Paul's Hospital, Providence Health Care, University of British Columbia, Vancouver, British Columbia, Canada.
Pasquale ChitanoCentre for Heart Lung Innovation, St. Paul's Hospital, Providence Health Care, University of British Columbia, Vancouver, British Columbia, Canada.
Chun Y SeowCentre for Heart Lung Innovation, St. Paul's Hospital, Providence Health Care, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-9653-8520

Funding

Canadian Government | Canadian Institutes of Health Research (CIHR) Project grant
6 · The paper itself

Abstract

Prolonged absence of deep inspiration (DI) increases airway resistance. The underlying mechanism is not entirely clear. We hypothesize that DI prohibition allows basal airway smooth muscle (ASM) tone to narrow and close airways over time, resulting in elevation of airway and lung resistance, as well as air trapping. We further hypothesize that DI or pharmacological bronchodilators can prevent or alleviate the resistance increase and air trapping. Physiological respiration was simulated in ex vivo sheep lungs. Lung resistance, elastance, and volume were measured using small tidal volume (120 mL), ventilation frequencies of 0.25 and 2 Hz, and transpulmonary pressure of 7.5 cmH

Indexed as

BronchoconstrictionBronchodilator AgentsInhalationTidal VolumeAirway ResistanceAlbuterolAnimalsLungMuscle, SmoothSheepAlbuterolBronchodilator Agentsair trappingdeep inspirationlung elastancelung resistancenegative pressure ventilation

Identifiers

PMID40590786

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.