Evidence map›Paper›PMID 40590705›Full record

ArticleFuture medicinal chemistry2025

Synthesis, antioxidant activity of novel sulfonamide and sulfonate organic salts bearing various heterocyclic moieties.

Didier Forest Kouganou Djossu, Joseph Tsemeugne, Paul Etoga Mbarga, Jean-De-Dieu Tamokou, Germaine Takongmo Matsuete, Armelle Tontsa Tsamo, Valerie Tedjon Sielinou, Edwin Mpho Mmutlane, Pierre Mkounga, Dieter Schollmeyer and 2 more

Abstract read
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In one paragraph

Article in Future medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Didier Forest Kouganou DjossuLaboratory of Natural Products and Applied Organic Synthesis (LANAPOS), Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Republic of Cameroon.
Joseph TsemeugneLaboratory of Natural Products and Applied Organic Synthesis (LANAPOS), Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Republic of Cameroon.ORCID 0000-0003-0923-8501
Paul Etoga MbargaLaboratory of Natural Products and Applied Organic Synthesis (LANAPOS), Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Republic of Cameroon.
Jean-De-Dieu TamokouResearch Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Republic of Cameroon.
Germaine Takongmo MatsueteResearch Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Republic of Cameroon.
Armelle Tontsa TsamoLaboratory of Natural Products and Applied Organic Synthesis (LANAPOS), Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Republic of Cameroon.
Valerie Tedjon SielinouLaboratory of Natural Products and Applied Organic Synthesis (LANAPOS), Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Republic of Cameroon.
Edwin Mpho MmutlaneResearch Centre for Synthesis and Catalysis, Department of Chemical Sciences, University of Johannesburg, Johannesburg, South Africa.
Pierre MkoungaLaboratory of Natural Products and Applied Organic Synthesis (LANAPOS), Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Republic of Cameroon.
Dieter SchollmeyerDepartment of Chemistry, Johannes Gutenberg University, Mainz, Germany.
Emmanuel Fondjo SopbuéLaboratory of Applied Synthetic Organic Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Republic of Cameroon.
Augustin Ephrem NkengfackLaboratory of Natural Products and Applied Organic Synthesis (LANAPOS), Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Republic of Cameroon.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe reactions of various heterocyclic primary amines with sulfonyl chloride derivatives or with sulfosalicylic acid results in the first case to the formation of sulfonamide derivatives and in the second case to the formation of sulfonate organic salts which are both hybrid molecule that integrate multiple pharmacophores into a single scaffold. MATERIALS AND

methodsThe novel sulfonamide derivatives 3 were obtained through mono-nucleophilic addition reactions of the corresponding primary amines to the appropriate sulfonyl derivative. In contrast, the sulfonate organic salts 5, 7 and 8 were formed as the result of an acid-base neutralization reaction, during which a molecule of amine captures the acid proton from the sulfosalicylic acid molecule. The antioxidant activity of the synthesized compounds is evaluated by determining their DPPH (2,2-Diphenyl-1-picrylhydrazyl) free radical scavenging activity as well as gallic acid equivalent antioxidant capacity (GEAC). RESULTS AND

conclusionThe structures of compounds 3, 5, 7 and 8 were confirmed through elemental analysis, IR (Infrared), UV-Vis (ultraviolet-visible),

Indexed as

AntioxidantsHeterocyclic CompoundsSulfonamidesSulfonic AcidsBiphenyl CompoundsMolecular StructurePicratesSalts1,1-diphenyl-2-picrylhydrazylAntioxidantsBiphenyl CompoundsHeterocyclic CompoundsPicratesSaltsSulfonamidesSulfonic Acids2-aminobenzothiazole2-aminopyrimidineantioxidant activityOrganic saltssulfonamide

Identifiers

PMID40590705
PMCPMC12279268

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.