ArticleJournal of the American Heart Association2025
Left Atrial Stiffness Is Increased in Pediatric Hypertrophic Cardiomyopathy and Offers Incremental Value in Predicting Major Adverse Cardiac Events in This Group.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Left Atrial Stiffness Identifies Children with Magnetic-Resonance-Imaging-Proven Acute Myocarditis Despite Preserved Left Ventricular Systolic Function.Pediatric cardiology · 2026Article
- Applications of speckle tracking echocardiography in paediatric and congenital heart disease: an expert consensus paper from AEPC Imaging Working Group.European heart journal. Imaging methods and practice · 2026Article
- Association of LVOT Gradient and LA Strain with Cardiac Events in Pediatric HCM.Pediatric cardiology · 2026Article
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundDetermining risk factors by echocardiography to prevent major adverse cardiac events (MACE) is crucial in pediatric patients with hypertrophic cardiomyopathy. Recent studies have shown that left atrial (LA) stiffness may serve as surrogate marker in children, to differentiate elevated pulmonary capillary wedge pressure from normal.
methodsWe retrospectively enrolled 239 pediatric patients with hypertrophic cardiomyopathy. They were divided into 2 groups: MACE (n=79) and non-MACE (n=160) groups. Noninvasive LA stiffness was calculated as the ratio of average E/e' to peak LA strain obtained by 2-dimensional speckle-tracking echocardiography. Baseline evaluation was defined as the echocardiogram performed at the time of referral, before the occurrence of a MACE, including appropriate implantable cardioverter-defibrillator intervention, myomectomy, heart transplant, or cardiac death.
resultsThe MACE group showed significantly decreased left ventricular peak longitudinal strain compared with the non-MACE group, with no significant difference in left ventricular ejection fraction. Peak LA strain was significantly reduced (22.5±7.1% versus 30.4±7.3%;
conclusionsLA stiffness is a newly described index, which may be of incremental value in predicting risk of MACE in pediatric patients with hypertrophic cardiomyopathy.
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