Evidence map›Paper›PMID 40590555›Full record

ArticlemBio2025

Deciphering cell cycle organization of

Mrinalini Batra, Clem Marsilia, Danya Awshah, Lauren M Hawkins, Chengqi Wang, Dale Chaput, Daria A Naumova, Elena S Suvorova

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Toxoplasma gondii SIR2A Promotes Tachyzoite Invasion via Lysine Deacetylase Activity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Assessing theBio-protocol · 2026
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mrinalini BatraDivision of Infectious Diseases, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.ORCID 0009-0005-9520-6144
Clem MarsiliaDivision of Infectious Diseases, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Danya AwshahDivision of Infectious Diseases, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Lauren M HawkinsDivision of Infectious Diseases, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Chengqi WangCollege of Public Health, University of South Florida, Tampa, Florida, USA.
Dale ChaputProteomics Core, College of Arts and Sciences, University of South Florida, Tampa, Florida, USA.
Daria A NaumovaDepartment of Biology, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
Elena S SuvorovaDivision of Infectious Diseases, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.ORCID 0000-0003-4482-8144

Funding

Cyclin-mediated control of Toxoplasma developmentR01AI141467 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI SUVOROVA, ELENA · 2020 to 2024
$1.9M
Regulation of apicomplexan mitosis coupled to buddingR01AI175640 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI Elena Suvorova · 2024 to 2026
$1.6M
Deciphering the composite S-phase in Toxoplasma gondiiR21AI178797 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI SUVOROVA, ELENA · 2023 to 2024
$413k
New reporter system for spatiotemporal visualization of Toxoplasma gondii growth and developmentR03AI155834 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI SUVOROVA, ELENA · 2021 to 2022
$150k
National Institute of Allergy and Infectious Diseases R01AI175640National Institute of Allergy and Infectious Diseases R03AI155834National Institute of Allergy and Infectious Diseases R21AI178797NIAID NIH HHS R01 AI141467NIAID NIH HHS R01 AI175640NIAID NIH HHS R03 AI155834NIAID NIH HHS R21 AI178797
6 · The paper itself

Abstract

In this study, we report the atypical cell cycle organization of the unicellular eukaryotic pathogen IMPORTANCE: The cell division rates directly correlate with the severity of the diseases caused by apicomplexan parasites. Despite its clinical importance, little is known about the apicomplexan cell cycle that controls parasite division rates. Previous studies implied that the apicomplexan cell cycle is organized differently from the cell cycle of their host cells. However, the order of cell cycle events had never been established. In the current study, we present evidence of the highly unusual organization of the

Indexed as

Cell CycleToxoplasmaCell DivisionDNA ReplicationHumansProtozoan ProteinsProtozoan ProteinsApicomplexaCdk-related kinasecell cycleFUCCIPCNA1Toxoplasma gondii

Identifiers

PMID40590555
PMCPMC12345243

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.