Evidence map›Paper›PMID 40590527›Full record

ArticlemSphere2025

Human papillomavirus 16 mitigates

Phoebe V Bridy, Jasmine C Cruz, Jada L Covington, Taharah I Islam, Catherine E Hadley, Kayla Tran, Rachel Fry, Bradley A Sheffield, Myrna Serrano, Gregory A Buck and 6 more

Abstract read
In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Anaerobe-Driven Inflammation and Epithelial Barrier Disruption in Genital HIV Acquisition.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
  6. Article
  7. Article
  8. The vaginal microbiome in HPV persistence and cervical cancer progression.Frontiers in cellular and infection microbiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Phoebe V BridyDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA.
Jasmine C CruzDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA.
Jada L CovingtonDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA.
Taharah I IslamDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA.
Catherine E HadleyDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA.
Kayla TranDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA.
Rachel FryDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA.
Bradley A SheffieldDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA.
Myrna SerranoDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA.
Gregory A BuckDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA.ORCID 0000-0003-4621-3987
Jinlei ZhaoVirginia Commonwealth University Massey Comprehensive Cancer Center, Richmond, Virginia, USA.
Katherine Y TossasVirginia Commonwealth University Massey Comprehensive Cancer Center, Richmond, Virginia, USA.
Craig MeyersDepartment of Microbiology and Immunology, Pennsylvania State College of Medicine, Hershey, Pennsylvania, USA.
Iain M MorganPhilips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA.ORCID 0000-0002-4949-3032
Claire D JamesPhilips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA.
Kimberly K JeffersonDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA.ORCID 0000-0003-1052-1988

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Keri R Maher · 1985 to 2026
$51.0M
The Vaginal Microbiome: Disease, Genetics and the EnvironmentUH3AI083263 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI BUCK, GREGORY ALLEN · 2010 to 2012
$6.8M
Determining how a Werner helicase (WRN) tumor suppressor complex regulates the human papillomavirus 16 life cycleR01DE029471 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI MORGAN, IAIN · 2021 to 2025
$2.8M
VCU Bridges to the Baccalaureate: From Dream to GoalR25GM102795 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI CHU, SHIJIAN, GOLDING, SARAH ELIZABETH · 2013 to 2022
$2.6M
Elucidating the Role of the Vaginal Microbiome in Racial Disparities in Precancerous Cervical Lesions: A Multi-level StudyK01CA285946 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Katherine Y Tossas · 2024 to 2026
$551k
"Role of the cytotoxin, CptA, from the emerging bacterial pathogen Sneathia vaginalis, in pathogenesis"R21AI166168 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI JEFFERSON, KIMBERLY KAY · 2023 to 2024
$427k
Mechanisms and consequences of human papillomavirus 16 E2 regulation of host gene transcriptionR21AI178143 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI MORGAN, IAIN · 2024 to 2025
$421k
NCI NIH HHS K01 CA285946NCI NIH HHS P30 CA016059NIAID NIH HHS R21 AI166168NIAID NIH HHS R21 AI178143NIAID NIH HHS UH3 AI083263NIDCR NIH HHS R01 DE029471NIGMS NIH HHS R25 GM102795NIH HHS K01CA285946NIH HHS R01DE029471,R21AI178143NIH HHS R21AI166168NIH HHS R25GM102795V Foundation for Cancer Research V2023-005Virginia Commonwealth University Breakthrough Award
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cervix UteriHuman papillomavirus 16KeratinocytesCoculture TechniquesFemaleHumansMicrobiotaPapillomavirus InfectionsRNA, Ribosomal, 16SVaginaRNA, Ribosomal, 16SHPVpolymicrobialpreterm birthSneathiavaginal microbiome

Identifiers

PMID40590527
PMCPMC12306162

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.