Evidence map›Paper›PMID 40590427›Full record

ArticleInternational journal of immunopathology and pharmacology

Kaempferide and Norbergenin avert aluminium chloride-induced amyloid β accumulation and neurocognitive shutdown via oxidative and apoptotic mechanisms.

Swathi Nalla, Suhasin Ganta, Sarad Pawar Naik Bukke, Nagaraju Bandaru, Hope Onohuean, Abdullateef Isiaka Alagbonsi

Abstract read
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In one paragraph

Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Swathi NallaDepartment of Pharmacology, Malla Reddy Pharmacy College, JNTUH, Hyderabad, Telangana, India.
Suhasin GantaDepartment of Pharmacology, GITAM School of Pharmacy, GITAM University, Visakhapatnam, Andhra Pradesh, India.ORCID 0000-0002-5099-4280
Sarad Pawar Naik BukkeDepartment of Pharmaceutics and Pharmaceutical Technology, Kampala International University, Western Campus, Ishaka, Bushenyi, Uganda.ORCID 0000-0002-5693-2953
Nagaraju BandaruDepartment of Pharmacology, School of Pharmaceutical Sciences, Sandip University, Nasik, Maharashtra, India.ORCID 0000-0003-2059-4849
Hope OnohueanBiopharmaceutics Unit, Department of Pharmacology & Toxicology, School of Pharmacy, Kampala International University, Ishaka-Bushenyi, Uganda.ORCID 0000-0002-1890-6324
Abdullateef Isiaka AlagbonsiDepartment of Physiology, School of Medicine and Pharmacy, College of Medicine and Health Sciences, University of Rwanda, Huye, Rwanda.ORCID 0000-0002-5462-9950

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the involvement of oxidative and apoptotic mechanisms in the possible neuroprotective effect of Kaempferide (KPD) and Norbergenin (NRG) against AlCl

introductionAluminium chloride (AlCl

methodsEighty-four male Wistar rats were randomly divided into two experimental models: prophylactic (pre-treatment with donepezil, KPD or NRG;

Indexed as

Amyloid beta-PeptidesApoptosisCognitionNeuroprotective AgentsOxidative StressAluminum ChlorideAluminum CompoundsAnimalsAntioxidantsChloridesDisease Models, AnimalMaleRatsRats, WistarAluminum ChlorideAluminum CompoundsAmyloid beta-PeptidesAntioxidantsChloridesNeuroprotective AgentsAluminium chlorideAmyloid-β proteinApoptosisKaempferideNeurocognitionNorbergeninOxidative stress

Identifiers

PMID40590427
PMCPMC12214314

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.