Evidence map›Paper›PMID 40590381›Full record

ArticleCell adhesion & migration2025

MiR-646 inhibited cell proliferation and migration by targeting P62 in glioma.

Fangyu Ye, Heng Zhang, Qianqian Chen, Yanping Gui, Geng Tian, Yuting Ye, Xin Chen, Haijuan Dong, Xiangshan Fan, Jun Chen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell adhesion & migration, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fangyu YeSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
Heng ZhangSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
Qianqian ChenSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
Yanping GuiSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
Geng TianSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
Yuting YePathology and PDX Efficacy Evaluation Center, China Pharmaceutical University, Nanjing, China.
Xin ChenPathology and PDX Efficacy Evaluation Center, China Pharmaceutical University, Nanjing, China.
Haijuan DongThe Public Laboratory Platform, China Pharmaceutical University, Nanjing, China.
Xiangshan FanDepartment of Pathology, Affiliated Nanjing Drum Tower Hospital of Nanjing University School of Medicine, Nanjing, China.
Jun ChenDepartment of Pathology, Affiliated Nanjing Drum Tower Hospital of Nanjing University School of Medicine, Nanjing, China.
RuiYing YuanDepartment of Medicament, College of Medicine, Tibet University, Lhasa, Tibet Autonomous Region, China.
Li ZhaoSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.
Juping YuSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MiR-646, a small non-coding RNA, poorly expressed in a variety of tumors. This study aimed to clarify the role of miR-646 and its underlying mechanisms in glioblastoma (GBM). In our study, we found that miR-646 mRNA levels were lower in tumor tissues than in non-cancer tissues. The ability of glioma cells to proliferate, invade, and migrate is diminished by miR-646 overexpression

Indexed as

Brain NeoplasmsCell MovementGliomaMicroRNAsSequestosome-1 Protein3' Untranslated RegionsAnimalsCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticGlioblastomaHeme Oxygenase-1HumansKelch-Like ECH-Associated Protein 1MaleMice3' Untranslated RegionsHeme Oxygenase-1KEAP1 protein, humanKelch-Like ECH-Associated Protein 1MicroRNAsNF-E2-Related Factor 2Sequestosome-1 ProteinSQSTM1 protein, humangliomamigrationMiR-646P62proliferation

Identifiers

PMID40590381
PMCPMC12218442

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.