Evidence map›Paper›PMID 40590377›Full record

ArticleAddiction biology2025

4-HIAA Blocks Methamphetamine-Induced Conditioned Place Preference in Mice Through Modulation of the 5-HT Pathway in the Nucleus Accumbens.

Yanan Wu, Ju Ran, Jinqiu Mo, Jing Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Addiction biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yanan WuTarim University, Alaer, Xinjiang, China.
Ju RanTarim University, Alaer, Xinjiang, China.
Jinqiu MoTarim University, Alaer, Xinjiang, China.
Jing WangRuijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.ORCID 0000-0002-0146-1963

Funding

Cultivation Star Project of RUIJIN HOSPITAL 2024PY281President Fund of Tarim University TDZKSS202318President Fund of Tarim University TDZKSS202319
6 · The paper itself

Abstract

4-hydroxyindole-3-acetic acid (4-HIAA) is a metabolite of psilocin. Here, we explored the ability of 4-HIAA to cross the blood-brain barrier and its potential effects on methamphetamine (METH)-induced conditioned place preference (CPP) in mice. Treatment with 1-mg/kg 4-HIAA inhibited CPP formation during the acquisition phase, promoted METH extinction and inhibited METH relapse. Furthermore, the regulatory effect of 4-HIAA on METH was underscored by altered 5-HT expression in the nucleus accumbens. Collectively, our findings provide novel insights into the molecular mechanisms of the 4-HIAA-induced blockade of the acquisition, extinction and reinstatement of METH-induced CPP.

Indexed as

Central Nervous System StimulantsHydroxyindoleacetic AcidMethamphetamineNucleus AccumbensSerotoninAnimalsConditioning, PsychologicalExtinction, PsychologicalMaleMiceMice, Inbred C57BLCentral Nervous System StimulantsHydroxyindoleacetic AcidMethamphetamineSerotonin4‐hydroxyindole‐3‐acetic acidconditioned place preferencemethamphetaminenucleus accumbenserotonin

Identifiers

PMID40590377
PMCPMC12210140

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.