Humanised Mice in Cutaneous Leishmaniasis-T-Cell Recruitment Into Human Skin Transplants After Leishmania major Infection.

Ling Miao, Henning Klapproth, Michael R Stepkes, Joanna Wegner, Esther von Stebut

Abstract read

In one paragraph

Article in Experimental dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Humanised Mice in Cutaneous Leishmaniasis-T-Cell Recruitment Into Human Skin Transplants After Leishmania major Infection.Experimental dermatology · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ling MiaoDepartment of Dermatology, Faculty of Medicine, University of Cologne, Cologne, Germany.

Henning KlapprothDepartment of Dermatology, Faculty of Medicine, University of Cologne, Cologne, Germany.

Michael R StepkesDepartment of Dermatology, Johannes Gutenberg University, Mainz, Germany.

Joanna WegnerDepartment of Dermatology, Johannes Gutenberg University, Mainz, Germany.

Esther von StebutDepartment of Dermatology, Faculty of Medicine, University of Cologne, Cologne, Germany.ORCID https://orcid.org/0000-0001-9802-9642

Funding

Deutsche Forschungsgemeinschaft 318346496

6 · The paper itself

Abstract

Treatment against leishmaniasis is associated with severe side effects, high costs, and parasitic resistance. Preclinical models such as humanised mice would aid therapeutic improvement or the development of a vaccine. We developed a model in which human skin transplants on immunodeficient mice are infected with Leishmania major. Parasite inoculation of the skin transplant led to a robust infection with increasing numbers of parasites in the skin and visceral organs. In addition, intraperitoneally co-administered allogeneic peripheral blood mononuclear cells (PBMCs) were strongly recruited to skin lesions, with ≥ 65% of the cells being positive for anti-human CD45; we identified ~20% CD4

Indexed as

Leishmania majorLeishmaniasis, CutaneousSkin TransplantationT-LymphocytesAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDisease Models, AnimalFemaleHumansLeukocytes, MononuclearMiceMice, SCIDSkin

Identifiers

PMID40590280

DOI10.1111/exd.70131

PMCPMC12210334

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.