ArticleExperimental dermatology2025
Precision at the Cutting Edge: Ex Vivo Confocal Microscopy for Perioperative Tumour Thickness Assessment in Melanoma.
Article in Experimental dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Rapid Assessment of Tumor Thickness in Cutaneous Squamous Cell Carcinoma Using Ex Vivo Confocal Microscopy.Cancers · 2026Article
- Precision at the Cutting Edge: Ex Vivo Confocal Microscopy for Perioperative Tumour Thickness Assessment in Melanoma.Experimental dermatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ex vivo confocal laser microscopy (EVCM) represents a promising diagnostic tool for the immediate assessment of fresh tissue, with significant potential for the management of melanoma. This study aimed to evaluate the accuracy of EVCM in determining perioperative tumour thickness, a critical factor in guiding treatment strategies for melanoma. A total of 27 confirmed melanomas of varying thickness and from multiple anatomic sites were analysed using both EVCM and gold standard conventional histopathology. Tumour thickness was independently measured using confocal tumour thickness (CTT) and histopathological tumour thickness (HTT) and subsequently compared using correlation analysis, Spearman's correlation coefficient and Bland-Altman plot. Our findings demonstrate a high correlation between HTT and CTT, with a Spearman's correlation coefficient of 0.94. Bland-Altman analysis revealed a mean difference of -0.19 ± 0.72 mm between CTT and HTT, indicating a strong agreement between the two measurement methods. These results underscore the potential of EVCM as a reliable tool for perioperative evaluation of tumour thickness in melanoma, potentially streamlining the decision-making process for surgical margins and improving patient outcomes. Further studies with larger sample sizes are warranted to validate these findings and explore the broader applicability of EVCM in clinical practice.
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Registered trials
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