ReviewMovement disorders clinical practice2026
From Hopelessness to Hope: Addressing Demoralization in Parkinson's Disease.
Review in Movement disorders clinical practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Perspective: Depression in Persons with Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Review
- Living with the Unknown: Intolerance of Uncertainty in Parkinson's Disease.Movement disorders clinical practice · 2026Review
- Experiences of Pacific Peoples and their 'āiga/kāinga/kāiga/vuvale living with Parkinsons: A qualitative study.PloS one · 2026Article
- Empowering People with Parkinson's: Reframing Self-Management in Parkinson's-A Critical Reflection of Current Practice.Healthcare (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundDemoralization is a pervasive yet under-recognized syndrome that manifests as profound hopelessness, helplessness, loss of motivation and purpose, and impaired coping capacity. Affecting over one-third of individuals in medical and neurological settings and 20-30% of the general population, demoralization is frequently misclassified as depression. However, its distinct phenomenology necessitates precise differentiation, particularly in Parkinson's disease (PD), where it can profoundly impact quality of life (QoL), social engagement, and treatment adherence, potentially contributing to a desire for hastened death.
objectiveTo synthesize the limited empirical and conceptual literature on demoralization in idiopathic PD, delineating its prevalence, phenomenology, and clinical-psychosocial correlates, clarifying distinctions from depression and apathy, and deriving evidence-informed recommendations for screening and intervention.
methodsA targeted search of MEDLINE, Embase, PsycINFO, and Web of Science (inception-22 May 2025), augmented by manual reference screening, identified eligible empirical and conceptual studies on demoralization in idiopathic PD, which were appraised against predefined criteria and thematically synthesized due to design heterogeneity.
resultsSeven papers were identified that fit the search criteria.
conclusionThis paper explores the clinical distinction between demoralization and depression in PWP and presents evidence-based intervention strategies. A compassionate, multidisciplinary, and personalized approach that incorporates the social and psychological aspects of PD may mitigate demoralization, supporting QoL and enhancing functional outcomes throughout disease progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.