SynthesisRenal failure2025
Impact of rapamycin on delayed graft function in kidney transplant recipients: a meta-analysis.
Synthesis in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the effect of rapamycin on DFG (delayed graft function in kidney transplant) recipients through a systematic review and meta-analysis.
methodsWe searched PubMed, Embase, Cochrane Library, and other databases for studies assessing rapamycin use in kidney transplantation with a focus on DGF. The search was conducted from the time of database construction to December 2024. Literature search and quality evaluation were conducted by two researchers. Data were analyzed using RevMan 5.3, with odds ratio (OR) for dichotomous outcomes and mean differences (MD) for continuous outcomes. The meta-analysis was performed with Q-
resultsNine studies (
conclusionsRapamycin significantly increases the risk and duration of DGF after kidney transplantation. However, it does not appear to affect long-term outcomes such as graft survival or rejection rates. These findings suggest that rapamycin should be used cautiously in transplant recipients at risk for DGF, and further studies are needed to optimize immunosuppressive strategies for this population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.