ReviewJournal of cosmetic dermatology2025
Vascular Embolism After Dull Needle Injection of Hyaluronic Acid Into Glabellar Wrinkles in Preformed Subdermal Tunnels: A Case Report and Review of the Literature.
Review in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Hyaluronidase Use in Aesthetic Medicine: Formulations, Safety, and Clinical Practice.Journal of clinical medicine · 2025Review
- Vascular Embolism After Dull Needle Injection of Hyaluronic Acid Into Glabellar Wrinkles in Preformed Subdermal Tunnels: A Case Report and Review of the Literature.Journal of cosmetic dermatology · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMore and more people inject fillers to fill their glabellar wrinkles, and complications are on the rise. CASE PRESENTATION: A 36-year-old woman was given a local infiltration anesthetic, and then a 22G sharp needle with an empty syringe was utilized to puncture several times near the subcutaneous tissue to form a tunnel. When we squeezed the tunnel, there was no bleeding, and then the needle was replaced by a 22G dull needle. The empty syringe was replaced by a hyaluronic acid gel syringe, and a small amount of hyaluronic acid was slowly given while withdrawing the needle. Skin swelling and bruising occurred 15 h after injection. Hyaluronase was injected into the ischemic area and treated with specific electromagnetic wave and vasodilators. Epidermal erosion appeared; however, it healed within 1 week without scar.
conclusionVascular embolism may be due to the needle piercing the blood vessel, a small amount of gel was forced into the pierced vessel, or the shear force of blood flow carried tiny gel particles into the vessel. The glabella is one of the most dangerous locations for hyaluronic acid injection because of possible vascular embolism. The use of preformed tunnels, thick dull needle, and aspiration without blood are not absolutely safe, and patients should be informed of the clinical manifestations of embolization before injection, and follow-up informed after injection.
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