ArticleKorean journal of anesthesiology2025
The 90% minimum effective volume and concentration of lidocaine for ultrasound-guided stellate ganglion blocks in adults: a biased-coin design, up-and-down sequential allocation trial.
Article in Korean journal of anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- The Optimal Effective Concentration of Spinal Anesthesia for Interlaminar Endoscopic Lumbar Discectomy: An Approach Based on the Biased Coin Design.Drug design, development and therapy · 2026Trial
- Determination of the ED90 and ED99 of Liposomal versus Conventional Bupivacaine for Ultrasound-Guided Stellate Ganglion Block: A Biased-Coin Design Study.Drug design, development and therapy · 2026Article
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Authors and funding
9 authors.
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Abstract
backgroundAs ultrasound imaging technology matured, stellate ganglion blocks (SGBs) have become increasingly precise and safe, and their use in clinical practice has become widespread. However, the 90% minimum effective volume (MEV90) and concentration (MEC90) of lidocaine for ultrasound-guided SGB remain unclear. We aimed to determine the MEV90 and MEC90 of lidocaine used in ultrasound-guided SGBs.
methodsPatients with indications for an SGB were recruited, without restrictions on sex or disease type. In this two-part study, we first determined the MEV90, and then used these results to determine the MEC90. The MEV90 and MEC90 of lidocaine for each subsequent patient were determined based on the previous patient's response, using a biased-coin design, up-and-down sequential allocation trial. The lidocaine volume and concentration intervals were 0.2 ml and 0.1%, respectively.
resultsIn total, 110 patients were enrolled (58 and 52 patients in the MEV90 and MEC90 studies, respectively). The MEV90 for 1% lidocaine was found to be 3.83 ml (95% CI [3.19-3.91]) and the extrapolated MEV99 was 3.97 ml (95% CI [3.95-5.29]). The MEC90 for lidocaine (4.0 ml) was found to be 0.38% (95% CI [0.32-0.41]) and the extrapolated MEC99 was 0.47% (95% CI [0.46-2.55]). Four patients in this study developed hoarseness, but no serious adverse events occurred.
conclusionsFor ultrasound-guided SGB in adults, we have determined the MEV90 of 1% lidocaine as 3.83 ml, and identified the MEC90 of 4 ml of lidocaine as 0.38%.
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