Evidence map›Paper›PMID 40590049›Full record

ReviewPublic health reviews2025

A Comprehensive Systematic Review and Meta-Analysis to Unravel the Noise-Dementia Nexus.

Soonmyung A Hwang, Aditi Singhvi, Lokesh Patil, Kimiya Gohari, Maayan Yitshak Sade, Elena Colicino, Melissa D Aldridge, Andrea A Baccarelli, Itai Kloog, Joel Schwartz and 5 more

Abstract readReview
In one paragraph

Review in Public health reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Urban greenspace and dementia: Measures, mechanisms, and methodological guidance.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Soonmyung A HwangIcahn School of Medicine at Mount Sinai, New York, NY, United States.
Aditi SinghviDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Lokesh PatilDepartment of Obstetrics, Gynecology and Reproductive Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, United States.
Kimiya GohariDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Maayan Yitshak SadeDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Elena ColicinoDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Melissa D AldridgeBrookdale Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Andrea A BaccarelliOffice of the Dean, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Itai KloogDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Joel SchwartzDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
R Sean MorrisonBrookdale Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Robert O WrightDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Henrik BøggildDepartment of Health Science and Technology, Aalborg University, Aalborg, Denmark.
Ali SheidaeiDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Pablo KnobelDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Residing in the Community with Dementia at the End of Life: Understanding Hospice Use and Residential SettingP30AG028741 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ALBERT L SIU · 2010 to 2026
$21.9M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Chris Gennings · 2014 to 2026
$21.3M
Air Particulate Pollution and Stress: Effects and Mechanisms for Long-term Maternal Obesity RisksR01ES032242 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI COLICINO, ELENA, WU, HAOTIAN · 2020 to 2024
$2.2M
NCATS NIH HHS UL1 TR004419NIA NIH HHS P30 AG028741NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R01 ES032242
6 · The paper itself

Abstract

Objectives: As the aging population grows, Alzheimer's disease and related dementias (ADRD) present a major public health challenge. Environmental noise, linked to stress and sleep disruption, may increase ADRD risk. We aimed to summarize the research literature on long-term noise exposure and ADRD. Methods: We conducted a systematic review and meta-analysis of studies investigating the association of long-term (≥1 year) noise exposure and ADRD assessed with standardized diagnostic criteria. Two reviewers independently screened studies, extracted data, and assessed risk of bias. Eligible studies reported hazard ratios (HR) or similar effect estimates with confidence intervals. Results: A multilevel random-effects meta-analysis of six longitudinal studies using 13 effect sizes found a significant association between long-term noise exposure and incident ADRD (HR: 1.15, 95% CI: 1.03-1.28). Interaction effects between noise source and dementia subtype were not statistically significant. Conclusion: Long-term noise exposure may contribute to ADRD risk. Heterogeneity between studies highlights the need for standardized exposure assessment and consideration of other environmental factors. Future research should include the exposome approach for identifying environmental drivers of dementia.

Indexed as

air pollutionAlzheimer’s disease and related dementias (ADRD)exposomemeta-analysisnoise

Identifiers

PMID40590049
PMCPMC12206670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.