Evidence map›Paper›PMID 40590021›Full record

ArticleVeterinary medicine international2025

Comparison of the Expression of Acetylated Histones H3 and H4 and the Deacetylase Enzymes HDACs 1, 2, and 6 in Neoplastic and Nonneoplastic Canine Mammary Tissues.

Igor Luiz Salardani Senhorello, Oscar Rodrigo Sierra Matiz, Isabela Cristina Canavari, Giovanni Vargas-Hernandez, Letícia Abrahão Anai, Roberto Andrés Navarrete Ampuero, Josiane Moraes Pazzini, Cibele Maria Prado, Flávio Vieira Meirelles, Rosemeri de Oliveira Vasconcelos and 1 more

Abstract read
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In one paragraph

Article in Veterinary medicine international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The role of epigenetic alterations in canine mammary cancer.The Journal of reproduction and development · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Igor Luiz Salardani SenhorelloDepartment of Veterinary Clinical Sciences and Surgery, School of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-2938-7267
Oscar Rodrigo Sierra MatizDepartment of Veterinary Clinical Sciences and Surgery, School of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, São Paulo, Brazil.
Isabela Cristina CanavariDepartment of Veterinary Clinical Sciences and Surgery, School of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, São Paulo, Brazil.
Giovanni Vargas-HernandezDepartment of Animal Health, National University of Colombia (UNAL), Bogotá, Colombia.
Letícia Abrahão AnaiDepartment of Veterinary Clinical Sciences and Surgery, School of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, São Paulo, Brazil.
Roberto Andrés Navarrete AmpueroIndependent Veterinary Practitioner, Catanduva, São Paulo, Brazil.
Josiane Moraes PazziniIndependent Veterinary Practitioner, São José do Rio Preto, São Paulo, Brazil.
Cibele Maria PradoDepartment of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo (USP), Pirassununga, São Paulo, Brazil.
Flávio Vieira MeirellesDepartment of Veterinary Medicine, School of Animal Science and Food Engineering, University of São Paulo (USP), Pirassununga, São Paulo, Brazil.
Rosemeri de Oliveira VasconcelosDepartment of Veterinary Clinical Sciences and Surgery, School of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, São Paulo, Brazil.
Mirela Tinucci-CostaDepartment of Veterinary Clinical Sciences and Surgery, School of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetic alterations play a crucial role in the pathogenesis of cancer, as changes in the expression of DNA-associated proteins can affect gene expression. However, these changes may be reversible following treatment. This study aimed to evaluate the expression of acetylated histones H3 and H4 and the deacetylase enzymes HDACs 1, 2, and 6 in canine mammary tissues in order to identify potential alterations due to aberrant protein expression in neoplastic tissues. For this purpose, mammary tissue samples from 91 canine patients were divided into four groups: G1, control group composed of mammary tissues with no histopathological changes (

Indexed as

canineepigeneticshypoacetylationmammary neoplasia

Identifiers

PMID40590021
PMCPMC12208763

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.