Evidence map›Paper›PMID 40589985›Full record

ArticleFrontiers in neurology2025

Effect of visual stimulation on epilepsy susceptibility in neonatal hypoglycemic brain injury rats during development.

Yifan Sun, Xiao Li, Yan Dong, Xiaoli Zhang, Ling Gan, Tianming Jia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yifan SunDepartment of Children's Development and Behavior Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Xiao LiDepartment of Pediatric Neurology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Yan DongDepartment of Pediatric Neurology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Xiaoli ZhangDepartment of Pediatric Neurology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Ling GanDepartment of Pediatric Neurology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Tianming JiaDepartment of Pediatric Neurology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the effect of visual stimulation on epilepsy susceptibility in neonatal hypoglycemic brain injury (HBIN) rats and its underlying mechanisms. Methods: Seventy-five 2-day-old Sprague-Dawley rats were divided into three groups: control (N, Results: (i) In the NH and NH-V groups, blood glucose decreased after insulin injection, with behavioral changes observed at 1-4 h. One rat in the NH group had spontaneous seizures. (ii) MRI at 15 days showed occipital lobe abnormalities in 50% of NH rats, with no changes in controls. (iii) In PTZ-induced seizures, the N group had significantly lower seizure scores than the NH group, with the NH-V group showing further reduction. (iv) BDNF and SYN expression were higher in the NH-V group compared to the NH group. Conclusion: Visual stimulation reduces epilepsy susceptibility in neonatal HBIN rats, likely through upregulation of BDNF and SYN expression in the occipital cortex.

Indexed as

BDNFepilepsy susceptibilityneonatal hypoglycemic brain injurySYNvisual stimulation

Identifiers

PMID40589985
PMCPMC12206811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.