ArticleFrontiers in medicine2025
The role of peripapillary vessel density and retinal nerve fiber layer thickness in diagnosing and monitoring myopic glaucoma.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Combining structural and microvascular parameters via machine learning for enhanced diagnosis of normal-tension glaucoma among highly myopic eyes: a prospective cross-sectional diagnostic accuracy study.BMC ophthalmology · 2026Article
- Macular vessel density as a novel biomarker for glaucoma diagnosis in highly myopic eyes: a multicenter study.Journal of translational medicine · 2025Article
- Differences in macular structure and microvasculature between high myopia and non-high myopia.Frontiers in medicine · 2025Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate changes in peripapillary vessel density (pVD) and retinal nerve fiber layer thickness (pRNFL) in highly myopic glaucoma patients compared to non-highly myopic glaucoma patients and healthy controls, and to evaluate their diagnostic capabilities using optical coherence tomography angiography (OCTA), and to explore the relationship between these biomarkers and visual function. Methods: A total of 382 eyes were recruited, including 101 highly myopic glaucoma eyes, 101 highly myopic control eyes, 90 non - highly myopic glaucoma eyes, and 90 non - highly myopic control eyes. Propensity score matching (PSM) was applied to balance age and axial length between groups. All subjects received comprehensive ophthalmic examinations. OCTA was used to measure pVD, spectral - domain OCT (SD - OCT) for pRNFL, and Humphrey 30-2 SITA standard visual field (VF) testing was performed. pVD and pRNFL were measured across eight peripapillary sectors. Pearson correlation and linear regression analyses were used to assess the relationships between pVD, pRNFL, and visual field mean sensitivity (VFMS). Receiver operating characteristic (ROC) curve analyses were carried out to evaluate the diagnostic performance. Results: Both highly myopic glaucoma and non-highly myopic glaucoma groups exhibited significantly lower pVD, pRNFL, and VFMS compared to their respective controls ( Conclusion: pVD and pRNFL are valuable diagnostic biomarkers for myopic glaucoma. pVD demonstrated a stronger correlation with visual function, making it a promising tool for early glaucoma diagnosis and monitoring in highly myopic patients. Integrating pVD with pRNFL enhances diagnostic precision, particularly in highly myopic patients.
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