Evidence map›Paper›PMID 40589910›Full record

ArticleERJ open research2025

Proteins associated with preserved ratio impaired spirometry.

Eva Lindberg, Xingwu Zhou, Annelie F Behndig, Kenneth Caidahl, Arne Egesten, Gunnar Engström, Jan E Engvall, Maria J Eriksson, Tove Fall, Anders Gummesson and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Eva LindbergDepartment of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.ORCID https://orcid.org/0000-0002-8552-4510
Xingwu ZhouDepartment of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
Annelie F BehndigDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Kenneth CaidahlDepartment of Clinical Physiology, Karolinska University Hospital, and Karolinska Institutet, Stockholm, Sweden.
Arne EgestenRespiratory Medicine and Allergology, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, Lund, Sweden.
Gunnar EngströmDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.ORCID https://orcid.org/0000-0002-8618-9152
Jan E EngvallCenter for Medical Image Science and Visualization, Linköping University, Linköping, Sweden.ORCID https://orcid.org/0000-0002-5716-5098
Maria J ErikssonDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Tove FallDepartment of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.
Anders GummessonDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Viktor HamreforsDepartment of Clinical Sciences, Lund University, Malmö, Sweden.ORCID https://orcid.org/0000-0002-8475-0866
Christer JansonDepartment of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.ORCID https://orcid.org/0000-0001-5093-6980
Åse JohnssonRegion Västra Götaland, Sahlgrenska University Hospital, Department of Radiology, Gothenburg, Sweden.
Anne LindbergDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.ORCID https://orcid.org/0000-0002-3292-7471
Maria MannilaDepartment of Cardiology, Karolinska University Hospital, Stockholm, Sweden.
Fredrik H NyströmDepartment of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Anna-Carin OlinOccupational and Environmental Medicine, School of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID https://orcid.org/0000-0001-6674-9020
C Magnus SköldDepartment of Respiratory Medicine and Allergy, Karolinska University Hospital Solna, Stockholm, Sweden.
Stefan SöderbergDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.ORCID https://orcid.org/0000-0001-9225-1306
Hanan TanashDepartment of Respiratory Medicine, Skåne University Hospital, Lund University, Malmö, Sweden.
Kjell TorénOccupational and Environmental Medicine, School of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Carl Johan ÖstgrenCenter for Medical Image Science and Visualization, Linköping University, Linköping, Sweden.
Andrei MalinovschiDepartment of Medical Sciences: Clinical Physiology, Uppsala University, Uppsala, Sweden.ORCID https://orcid.org/0000-0002-4098-7765
Anders BlombergDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.ORCID https://orcid.org/0000-0002-2452-7347

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Preserved ratio impaired spirometry (PRISm) is a spirometry pattern of interest regarding incident airflow obstruction and higher mortality risk. We applied a proteomic approach to gain more insight into the biological mechanisms associated with PRISm. Methods: From the population-based Swedish Cardiopulmonary Bioimage Study (SCAPIS), participants in the Main (n=4835) and Pilot (n=1054) studies, were included as discovery and replication cohorts. The lower limit of normal (LLN) of post-bronchodilator forced expiratory volume in 1 s (FEV Results: Eight proteins were associated with PRISm and replicated: tumour necrosis factor receptor superfamily member 10A, interleukin-6, paraoxonase 3 (negative association), renin, urokinase plasminogen activator surface receptor (U-PAR), E-selectin, matrix metalloproteinase 7 and chitinase-3-like protein 1. Interleukin-6 and U-PAR were also associated with moderate-severe CAL and E-selectin with RSP. In addition, five other proteins were associated with moderate-severe CAL and three with RSP. Conclusion: Protein profile in PRISm differs from other spirometric patterns suggesting specific disease mechanisms.

Identifiers

PMID40589910
PMCPMC12208607

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.