ArticleERJ open research2025
Open-source, three-dimensionally printed manifolds for exposure studies using human airway epithelial cells.
Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- A Human Vocal Fold Organ-On-Chip for Studying Platform-Dependent Mucosal Responses to Particulate Matter.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rationale: Methods: A chamber-style exposure system and the designed manifolds were evaluated for exposure uniformity Results: The manifolds produced less variation in simulations and physical deposition of FITC-dextran aerosol across well plates compared to the chamber system. Distinct doses of cannabis concentrate vapour were delivered to well plates with minimal variation among wells. Whole tobacco smoke exposure using the manifold system induced functional changes in Calu-3 barrier function, cytokine production (interleukin (IL)-6 and IL-8) and cell membrane potential. Cannabis smoke led to reduced primary HAEC barrier function in a dose- and strain-dependent manner. Conclusions: Our data demonstrate the feasibility and the validity of our open-source 3D printed manifolds for use in studying multiple exposures and position our designs as an accessible option in parallel with commercially available systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.