Evidence map›Paper›PMID 40589899›Full record

ArticleMacromolecules2024

Lipid Membrane Leaflets Unzip upon Hybridization with Polymer-Rich Nanodomains.

James F Tallman, Nurila Kambar, Cecília Leal, Antonia Statt

Abstract read
In one paragraph

Article in Macromolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Membrane-Inserting α‑Lipid Polymers: Understanding Lipid Membrane Insertion and Effect on Membrane Fluidity.Chemistry of materials : a publication of the American Chemical Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

James F TallmanDepartment of Materials Science and Engineering, Grainger College of Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Nurila KambarDepartment of Materials Science and Engineering, Grainger College of Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.ORCID 0000-0001-6984-3370
Cecília LealDepartment of Materials Science and Engineering, Grainger College of Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.ORCID 0000-0001-5972-508X
Antonia StattDepartment of Materials Science and Engineering, Grainger College of Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.ORCID 0000-0002-6120-5072

Funding

Endosomal escape of lipid-based nanoparticles comprising Gaussian curvature lipidsR01GM143723 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI LEAL, CECILIA MARIA · 2022 to 2025
$1.7M
Biophysical and genetic cues regulating lipid droplet packaging and alterations in obesityR01DK130317 · NIDDK · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI ANAKK, SAYEEPRIYADARSHINI, LEAL, CECILIA MARIA · 2021 to 2023
$1.5M
NIDDK NIH HHS R01 DK130317NIGMS NIH HHS R01 GM143723
6 · The paper itself

Abstract

There is a long-term interest in creating artificial biomimetic membranes where self-assembled phospholipid bilayers are selectively permeabilized by synthetic channel-like molecules. One example is the coassembly of amphiphilic block copolymers with phospholipids into a hybrid membrane. Hybrid phospholipid block copolymer bilayers display many properties, seen in biomembranes such as selective transport phenomena, synergistic elastic properties, and structural phase transformations. Just like in biomembranes, these fundamental properties of hybrid bilayers are often regulated by lateral phase separation. Understanding the molecular and physical cues that determine the formation of rafts or domains in hybrid membranes, their size, and morphology is paramount to elucidating and programming their function. Employing a combination of coarse-grained molecular dynamics simulations and high-resolution cryogenic electron microscopy, we discovered that phosphatidylcholine-cholesterol bilayers hybridized with poly(butadiene-

Identifiers

PMID40589899
PMCPMC12208625

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.