Evidence map›Paper›PMID 40589858›Full record

ArticlePeerJ2025

Structural and functional neuroimaging of hippocampus to study adult neurogenesis in long COVID-19 patients with neuropsychiatric symptoms: a scoping review.

Jayakumar Saikarthik, Ilango Saraswathi, Bijaya Kumar Padhi, Muhammad Aaqib Shamim, Nasser Alzerwi, Abdulaziz Alarifi, Aravind P Gandhi

Abstract readScoping Review
In one paragraph

Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jayakumar SaikarthikDepartment of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Majmaah University, Al Majmaah, Saudi Arabia.
Ilango SaraswathiDepartment of Physiology, Madha Medical College and Research Institute, Chennai, India.
Bijaya Kumar PadhiDepartment of Community Medicine and School of Public Health, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Muhammad Aaqib ShamimDepartment of Pharmacology, All India Institute of Medical Sciences, Jodhpur, India.
Nasser AlzerwiDepartment of Surgery, College of Medicine, Majmaah University, Al Majmaah, Saudi Arabia.
Abdulaziz AlarifiDepartment of Basic Sciences, College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Aravind P GandhiDepartment of Community Medicine, All India Institute of Medical Sciences, Nagpur, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Worsening of neuropsychiatric and neurodegenerative disorders occurs in COVID-19. Impaired adult neurogenesis is linked to most of the neuropsychiatric symptoms and disorders. Aim: The current scoping review identified and mapped the available evidence on adult neurogenesis in long COVID-19, at a global level following the JBI methodology for scoping reviews and followed the framework by Arksey and O'Malley. Method: Original studies focusing on structural and functional neuroimaging of the hippocampus to study adult neurogenesis in long COVID-19 were included in the review. Studies published in English language with no restriction on the time of publication were searched using the specified search strategy in PubMed, Web of Science, Embase, and SCOPUS. Articles obtained from the database search were collated and uploaded into the Nested Knowledge AutoLit semi-automated systematic review platform for data extraction. Results: The current review provides evidence of the potential alterations in adult neurogenesis in long COVID-19 and its potential link to neuropsychiatric sequelae of long COVID-19, with further research required to validate this assertion. Conclusion: This review proposes conceptual and methodological approaches for future investigations to address existing limitations and elucidate the precise role of adult neurogenesis in the pathophysiology and treatment of long COVID-19.

Indexed as

COVID-19Functional NeuroimagingHippocampusMental DisordersNeurogenesisAdultHumansMagnetic Resonance ImagingNeuroimagingSARS-CoV-2COVID-19HippocampusLong COVIDNeurogenesisNeuroimaging

Identifiers

PMID40589858
PMCPMC12208109

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.