Evidence map›Paper›PMID 40589754›Full record

ArticleFrontiers in immunology2025

A novel and safe SmartCap

Rachel Kim, Tae-Gi Uhm, Jisu Kim, Dayeon Woo, Uk-Il Kim, Xue Meng, Byounggu Yang, Suhyeon Kim, Heejene Kim, Jonghyeon Kim and 14 more

Abstract readClinical Trial, Phase IMulticenter Study
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Rachel Kim *R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.
Tae-Gi Uhm *R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.
Jisu KimR&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.
Dayeon WooR&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.
Uk-Il KimR&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.
Xue MengR&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.
Byounggu YangR&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.
Suhyeon KimR&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.
Heejene KimR&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.
Jonghyeon KimR&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.
Sunkyung YoonDivision of Clinical Research for vaccine, Center for Vaccine Research, National Institute of Infectious Diseases, Korea National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju, Republic of Korea.
Joo-Young LeeR&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.
Byungkyun KimR&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.
Dongheon ChoR&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.
Duckho ChangR&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.
Young-Hwan ChoR&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.
Kanghyun ChoiR&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.
WonSeok GwakDivision of Clinical Research for vaccine, Center for Vaccine Research, National Institute of Infectious Diseases, Korea National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju, Republic of Korea.
Hoon-Woo LeeR&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.
Jieun BangR&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.
Elizabeth HellströmBe Part Research (PTY) Ltd., Paarl, South Africa.
Byoungguk KimDivision of Clinical Research for vaccine, Center for Vaccine Research, National Institute of Infectious Diseases, Korea National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju, Republic of Korea.
Kyungjin Kim *R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.
Joo-Sung Yang *R&D Center, ST Pharm Co., Ltd., Seoul, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have developed a 5'-capping library screening (CLS) method using over 30 different novel cap analogues. The optimal 5'-cap for the coronavirus disease 2019 (COVID-19) mRNA vaccine STP2104 was selected and applied. This is the first report to describe the proven safety of the novel cap analogue, SmartCap

Indexed as

COVID-19COVID-19 VaccinesSARS-CoV-2AdolescentAdultAntibodies, NeutralizingAntibodies, ViralFemaleHumansImmunogenicity, VaccineMaleMiddle AgedmRNA VaccinesVaccines, SyntheticYoung AdultAntibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesmRNA VaccinesVaccines, Synthetic5’-cap analogueCapping Library ScreeningCOVID-19human clinical trial studymRNA vaccineSARS-CoV-2SmartCap®STP2104

Identifiers

PMID40589754
PMCPMC12206861

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.