ArticleOrthopedic reviews2025
Revolutionizing Nonunion Treatment: The Expanding Role of Local Biological Therapies.
Article in Orthopedic reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Evolving Treatment Options for Spinal Pain: Balancing Innovation and Affordability in Regenerative Medicine.Current pain and headache reports · 2026Review
- Evaluation of mesenchymal stem cells' bone repair capacity via osteogenic lineage differentiation in experimental nonunion fractures.BMC musculoskeletal disorders · 2026Article
- Orthobiologics in Trauma: Current Trends, Future Directions, and Regenerative Strategies.Cureus · 2026Review
- Intradermal Application of Allogenic Wharton's Jelly Mesenchymal Stem Cells for Chronic Post-Thoracotomy Wound in an Elderly Patient After Coronary Artery Bypass Grafting: Clinical Case with Brief Literature Review.Diseases (Basel, Switzerland) · 2026Article
- Spatial multi-omics decoding of the fracture nonunion niche: from immune-vascular-skeletal crosstalk to precision regeneration.Frontiers in medicine · 2026Review
- Nonunion in Long Bone Fractures: A Comprehensive Review of Current Treatment Strategies.Cureus · 2025Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The diagnosis and treatment of long bone nonunion remains a historical challenge in the field of orthopedics. Bone nonunion management encompasses surgical and non-surgical options. This review discusses the potential use of untraditional methods in their treatment such as orthobiologics. The cornerstone of local biological therapies lies in their ability to directly stimulate the biological processes essential for bone repair. This precision targeting ensures that bone healing pathways are activated specifically where needed, enhancing both the rate and quality of union. It particularly addresses the use of biologic agents and the possibility of their combination with biomaterials to enhance their stability, delivery, and osteoconductive properties. The aim of this review is to obtain an updated point of view regarding the management of nonunion of the bone as well as expanding on the latest innovations aiming to create a shift from passive biologic supplementation to active regenerative engineering.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.