ReviewBiomedical reports2025
Therapeutic insights and molecular mechanism linking melatonin signaling and membranous nephropathy (Review).
Review in Biomedical reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Melatonin receptor signaling in human pathologies: from molecular mechanisms to therapeutic targets.Function (Oxford, England) · 2026Review
- The Protective Effects of N-Acetylserotonin Against Cisplatin-Induced Renal Injury: A Biochemical and Histopathological Study.International journal of molecular sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endogenous melatonin is synthesized at night by specific enzymes and exerts various physiological effects through both melatonin receptor-dependent and -independent pathways. Moreover, exogenous melatonin has been demonstrated to have pleiotropic therapeutic effects on a range of pathological conditions, including renal diseases. The melatonin signaling pathway involves specific enzymes responsible for melatonin synthesis and cellular responses mediated by melatonin, which are evolutionarily conserved in both brain and peripheral tissues. Although the physiological functions of the melatonin-mediated signaling pathway are well-documented across multiple organ systems, its effects on the kidney are less recognized. The present review summarizes the expression levels of melatonin biosynthesis enzymes and melatonin receptors, as well as their roles in renal tissue under pathological conditions such as membranous nephropathy (MN). The present review explores the molecular mechanisms regulating the expression of aryl-alkyl-amine N-acetyl-transferase, nuclear enriched abundant transcript 1 and melatonin receptor 1A (MTNR1A) in renal tubular epithelial cells. Overall, the present review provides new insights into the role of MTNR1A in the pathology, treatment and prevention of MN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.